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Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets

John M. Bennett, Sunil K. Narwal, Stephanie Kabeche, et al.

Inferring protein from mRNA concentrations using convolutional neural networks

Patrick Maximilian Schwehn, Pascal Falter-Braun

Double-strand breaks in facultative heterochromatin require specific movements and chromatin changes for efficient repair

Marieke R. Wensveen, Aditya A. Dixit, Serafin U. Colmenares, et al.

Patterned embryonic invagination evolved in response to mechanical instability

Bruno C. Vellutini, Marina B. Cuenca, Abhijeet Krishna, et al.

AND

Divergent evolutionary strategies preempt tissue collision in fly gastrulation

Bipasha Dey, Verena Kaul, Girish Kale, et al.

Multi-pass, single-molecule nanopore reading of long protein strands with single-amino acid sensitivity

Keisuke Motone, Daphne Kontogiorgos-Heintz, Jasmine Wee, et al.

A direct experimental test of Ohno’s hypothesis

Ljiljana Mihajlovic, Bharat Ravi Iyengar, Florian Baier, et al.

Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery

Jayne Aiken, Erika L. F. Holzbaur

Discussion

Inference of drug off-target effects on cellular signaling using Interactome-Based Deep Learning

Nikolaos Meimetis, Douglas A. Lauffenburger, Avlant Nilsson

The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity

Hasan Mamar, Roberta Fajka-Boja, Mónika Mórocz, et al.

Ancient origins of complex neuronal genes

Matthew J. McCoy, Andrew Z. Fire

Discussion

Short N-terminal disordered regions and the proline-rich domain are major regulators of phase transitions for full-length UBQLN1, UBQLN2 and UBQLN4

Thuy P. Dao, Anitha Rajendran, Sarasi K. K. Galagedera, et al.

Glutamate helps unmask the differences in driving forces for phase separation versus clustering of FET family proteins in sub-saturated solutions

Mrityunjoy Kar, Laura T. Vogel, Gaurav Chauhan, et al.

Discussion