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Cell polarity linked to gravity sensing is generated by protein translocation from statoliths to the plasma membrane

Takeshi Nishimura, Shogo Mori, Hiromasa Shikata, et al.

AND

Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants

Jiayue Chen, Renbo Yu, Na Li, et al.

Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing

Fumiyuki Hatanaka, Keiichiro Suzuki, Kensaku Shojima, et al.

Discussion

Inhibition of Centrosome Clustering Reduces Cystogenesis and Improves Kidney Function in Autosomal Dominant Polycystic Kidney Disease

Tao Cheng, Aruljothi Mariappan, Ewa Langner, et al.

Laboratory evolution of flies to morphogen dosage via rapid maternal changes reveals predictable outcomes

Xueying C. Li, Lautaro Gandara, Måns Ekelöf, et al.

Actin nucleators safeguard replication forks by limiting nascent strand degradation

Jadwiga Nieminuszczy, Peter R. Martin, Ronan Broderick, et al.

Discussion

BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote replication fork stability and continuous DNA synthesis

Daniel Salas-Lloret, Néstor García-Rodríguez, Lisanne Giebel, et al.

Single-strand mismatch and damage patterns revealed by single-molecule DNA sequencing

Mei Hong Liu, Benjamin Costa, Una Choi, et al.

The phosphodiesterase 2A regulates lymphatic endothelial development via cGMP-mediated control of Notch signaling

Claudia Carlantoni, Leon Liekfeld, Sandra A. Hemkemeyer, et al.

Sex-determining 3D regulatory hubs revealed by genome spatial auto-correlation analysis

Irene Mota-Gómez, Juan Antonio Rodríguez, Shannon Dupont, et al.

Discussion

Motion of single molecular tethers reveals dynamic subdomains at ER-mitochondria contact sites

Christopher J. Obara, Jonathon Nixon-Abell, Andrew S. Moore, et al.

A specialized mRNA translation circuit instated in pluripotency presets the competence for cardiogenesis in humans

Deniz Bartsch, Kaustubh Kalamkar, Gaurav Ahuja, et al.

Gigaxonin is required for intermediate filament transport

Bhuvanasundar Renganathan, James P Zewe, Yuan Cheng, et al.