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Orphan CpG islands boost the regulatory activity of poised enhancers and dictate the responsiveness of their target genes

Tomás Pachano, Víctor Sánchez-Gaya, María Mariner-Faulí, et al.

The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development

Trisha A. Macrae, Miguel Ramalho-Santos

Sexually Dimorphic DNA Damage Responses and Mutation Avoidance in the Mouse Germline

Jordana C. Bloom, John C. Schimenti

Primate naïve pluripotent stem cells stall in the G1 phase of the cell cycle and differentiate prematurely during embryo colonization

Irène Aksoy, Cloé Rognard, Anaïs Moulin, et al.

Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics

S Basu, O Shukron, A Ponjavic, et al.

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Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy

Miles K. Huseyin, Robert J. Klose

Transcriptional control of apical protein clustering drives de novo cell polarity establishment in the early mouse embryo

Meng Zhu, Peizhe Wang, Charlotte E. Handford, et al.

Trophectoderm Potency is Retained Exclusively in Human Naïve Cells

Ge Guo, Giuliano Giuseppe Stirparo, Stanley Strawbridge, et al.

Membrane tension mediated mechanotransduction drives fate choice in embryonic stem cells

Henry De Belly, Philip H. Jones, Ewa K. Paluch, et al.

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Cell surface mechanics gate stem cell differentiation

Martin Bergert, Sergio Lembo, Danica Milovanović, et al.

Differential regulation of lineage commitment in human and mouse primed pluripotent stem cells by NuRD

Ramy Ragheb, Sarah Gharbi, Julie Cramard, et al.

DRP1-mediated regulation of mitochondrial dynamics determines the apoptotic response upon embryonic differentiation

Barbara Pernaute, Juan Miguel Sánchez Nieto, Salvador Pérez-Montero, et al.

Differences in mitochondrial activity trigger cell competition during early mouse development

Ana Lima, Gabriele Lubatti, Jörg Burgstaller, et al.

Glucose metabolism distinguishes TE from ICM fate during mammalian embryogenesis

Fangtao Chi, Mark S. Sharpley, Raghavendra Nagaraj, et al.

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