Neurogenomics PhD student on a quest to chart how individual genetic predispositions operate to enhance or reduce environmental pollutants’ deleterious effects on human neurodevelopment. From single cells to population cohorts, one brain organoid at a time.
Dissecting Gene Regulatory Networks Governing Human Cortical Cell Fate
Manuel Lessi
High-throughput single-cell CRISPRi screens stratify neurodevelopmental functions of schizophrenia-associated genes
Manuel Lessi, Riccardo Nagni
Polystyrene nanoplastics promote neurodegeneration by catalyzing TDP43 hyperphosphorylation
Manuel Lessi
Alzheimer’s Disease Patient Brain Extracts Induce Multiple Pathologies in Vascularized Neuroimmune Organoids for Disease Modeling and Drug Discovery
Manuel Lessi
Fetal brain response to maternal inflammation requires microglia
Manuel Lessi
Single-cell epigenomic reconstruction of developmental trajectories in human neural organoid systems from pluripotency
Manuel Lessi
November in preprints – DevBio & Stem cell biology
preLighters with expertise across developmental and stem cell biology have nominated a few developmental and stem cell biology (and related) preprints posted in November they’re excited about and explain in a single paragraph why. Concise preprint highlights, prepared by the preLighter community – a quick way to spot upcoming trends, new methods and fresh ideas.
| List by | Aline Grata et al. |
October in preprints – DevBio & Stem cell biology
Each month, preLighters with expertise across developmental and stem cell biology nominate a few recent developmental and stem cell biology (and related) preprints they’re excited about and explain in a single paragraph why. Short, snappy picks from working scientists — a quick way to spot fresh ideas, bold methods and papers worth reading in full. These preprints can all be found in the October preprint list published on the Node.
| List by | Deevitha Balasubramanian et al. |