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Megane Rayer

I am a postdoc in Dr. Gregg Gundersen’s lab (Columbia University). I am working on mammary gland in 3D culture. I study the mechanical role of the nucleus via the LINC complex in epithelia architecture. Before that, I did my PhD in Magali Suzanne’s lab in Toulouse (France). I found for the first time that the nucleus is relocated in basal side in apoptotic cells to serve of anchor point to a myosin cable generating an apico-basal forces, important for the drosophila leg morphogenesis. I am very interesting and very curious to understand how the nucleus can play other role than genome protector, especially through its mechanical properties. I am also interested to understand how the nuclear physical features can influence cell behaviors and morphogenesis.

 

Megane Rayer has added 3 preLight posts

LINC complex alterations are a hallmark of sporadic and familial ALS/FTD

Riccardo Sirtori, Michelle Gregoire, Emily Potts, et al.

Selected by 03 June 2024

Megane Rayer et al.

Cell Biology

Actin polymerization drives lumen formation in a human epiblast model

Dhiraj Indana, Andrei Zakharov, Youngbin Lim, et al.

Selected by 05 April 2024

Megane Rayer, Rivka Shapiro

Biophysics

An oncogenic isoform of septin 9 promotes the formation of juxtanuclear invadopodia by reducing nuclear deformability

Joshua Okletey, Dimitrios Angelis, Tia M. Jones, et al.

Selected by 31 July 2023

Megane Rayer

Cancer Biology

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