Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche

This preprint has now been reviewed and published at eLife. The authors have made multiple additions, including a striking demonstration that bone marrow megakaryocytes are attached to their extracellular matrix cages through showing that cages are retained on megakaryocytes isolated from dissociated bone marrow. Movies allow us to better appreciate the 3-dimensional structure of cages.…