I am a research group leader and Lecturer in Respiratory Pharmacology at King’s College London. My research currently addresses how the specialised endothelial cells found in the lungs control inflammatory responses. I have a PhD in Pharmacology from King’s College London and have previously worked as a postdoctoral fellow at the Babraham Institute, Cambridge and at the University of California, San Francisco (UCSF).
Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche
Simon Cleary
Integrin conformation-dependent neutrophil slowing obstructs the capillaries of the pre-metastatic lung in a model of breast cancer
Simon Cleary
G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics
Simon Cleary
Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche
This preprint has now been reviewed and published at eLife. The authors have made multiple additions, including a striking demonstration that bone marrow megakaryocytes are attached to their extracellular matrix cages through showing that cages are retained on megakaryocytes isolated from dissociated bone marrow. Movies allow us to better appreciate the 3-dimensional structure of cages.…
| Posted on | 5 December 2025 |
Integrin conformation-dependent neutrophil slowing obstructs the capillaries of the pre-metastatic lung in a model of breast cancer
This study has now been peer reviewed and published at Cell Reports. In the preprint, the authors showed that the M18/2 β2 integrin antibody increases the speed of neutrophil crawling and improves microvascular perfusion within lung tissue in a mouse model of breast cancer. Based on the results of these studies, they proposed that integrin-dependent…
| Posted on | 7 May 2026 |