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SQ3370, the first clinical click chemistry-activated cancer therapeutic, shows safety in humans and translatability across species

Sangeetha Srinivasan, Nathan A. Yee, Michael Zakharian, et al.

Selected by 06 May 2023

Zhang-He Goh

Pharmacology and Toxicology

Spatial and single-cell transcriptomics reveal neuron-astrocyte interplay in long-term memory

Wenfei Sun, Zhihui Liu, Xian Jiang, et al.

Selected by 03 May 2023

Jessica Chevallier

Neuroscience

Inhibition of Centrosome Clustering Reduces Cystogenesis and Improves Kidney Function in Autosomal Dominant Polycystic Kidney Disease

Tao Cheng, Aruljothi Mariappan, Ewa Langner, et al.

Selected by 24 April 2023

Fiona Macleod

Maintenance of pluripotency in the entire ectoderm enables neural crest formation

Ceren Pajanoja, Jenny Hsin, Bradley Olinger, et al.

Selected by 20 April 2023

Andrew Montequin

Developmental Biology

Phospho-seq: Integrated, multi-modal profiling of intracellular protein dynamics in single cells

John D. Blair, Austin Hartman, Fides Zenk, et al.

Selected by 19 April 2023

Benjamin Dominik Maier

Molecular Biology

A data-driven Boolean model explains memory subsets and evolution in CD8+ T cell exhaustion

Geena V. Ildefonso, Stacey D. Finley

Selected by 10 April 2023

Benjamin Dominik Maier

Systems Biology

Flat clathrin lattices are linked to metastatic potential in colorectal cancer

Charlotte Cresens, Guillermo Solis-Fernandez, Astha Tiwari, et al.

Selected by 06 April 2023

Emily Chan

Biophysics

Humoral and T-cell-mediated responses to a pre-clinical Zika vaccine candidate that utilizes a unique insect-specific flavivirus platform

Danielle L. Porier, Awadalkareem Adam, Lin Kang, et al.

Selected by 24 March 2023

Lucy Bowden

Immunology
Alumni

marmite defines a novel conserved neuropeptide family mediating nutritional homeostasis

AP Francisco, I Tastekin, AB Fernandes, et al.

Selected by 22 March 2023

Pablo Ranea Robles, Cláudia Gil

Physiology

Insm1 regulates the development of mTECs and immune tolerance

Wehuai Tao, Yiqiu Wei, Zhihuan Ye, et al.

Selected by 28 February 2023

Marina Schernthanner, Jessica Chevallier

Bioinformatics
Alumni

The phosphodiesterase 2A regulates lymphatic endothelial development via cGMP-mediated control of Notch signaling

Claudia Carlantoni, Leon Liekfeld, Sandra A. Hemkemeyer, et al.

Selected by 20 February 2023

Andreas van Impel, Sanjay Sunil Kumar

Developmental Biology
Alumni

A transcriptional and regulatory map of mouse somitogenesis

Ximena Ibarra-Soria, Elodie Thierion, Gi Fay Mok, et al.

Selected by 20 February 2023

Sergio Menchero

Developmental Biology
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