Hi! I am a post-doctoral researcher working with Dr. Joo-Hyeon Lee at the Cambridge Stem Cell Institute, UK. A key research interest of mine has been to understand the interaction of epithelial cells with their microenvironment during tissue repair and disease progression.
My graduate research focused on understanding mechanisms that govern the plasticity of ovarian cancer cells and its contribution to therapy resistance. Observations from my PhD fuelled my interest in the physical and chemical crosstalk between different cell populations that facilitate optimal organ function. These musings led to me joining Dr. Lee’s group in Cambridge wherein I am attempting to understand how the lung epithelium instructs its niche in response to injury and generates an environment most conducive to regeneration. My project involves lineage tracing of epithelial and stromal cell populations in mouse models of lung injury, establishment of organoid and ex vivo explant models to capture cell-fate conversion and single cell transcriptomics to delineate the complexity of stem cell-stroma interactions.
Three-axis classification of mouse lung mesenchymal cells reveals two populations of myofibroblasts
Sagar Varankar
Epithelial-mesenchymal plasticity determines estrogen receptor positive (ER+) breast cancer dormancy and reacquisition of an epithelial state drives awakening
Sagar Varankar
Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates
Sagar Varankar
TAZ/TEAD complex regulates TGF-β1-mediated fibrosis in iPSC-derived renal organoids
Sagar Varankar