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Dosage-sensitive RBFOX2 autoregulation promotes cardiomyocyte differentiation by maturing the transcriptome

Mengmeng Huang, Feria A. Ladha, Yunxia Wang, et al.

Selected by 06 December 2025

Theodora Stougiannou

Developmental Biology

A high-coverage genome from a 200,000-year-old Denisovan

Stéphane Peyrégne, Diyendo Massilani, Yaniv Swiel, et al.

AND

A global map for introgressed structural variation and selection in humans

PingHsun Hsieh, Natthapon Soisangwan, David S. Gordon, et al.

Selected by 02 December 2025

Siddharth Singh

Evolutionary Biology

Citrobacter rodentium infection activates colonic lamina propria group 2 innate lymphoid cells

Rita Berkachy, Vishwas Mishra, Priyanka Biswas, et al.

Selected by 02 December 2025

André Luiz Amorim Costa, Marcus Oliveira

Immunology

Post-translational Tuning of Human Cortical Progenitor Neuronal Output

Julien Pigeon, Tamina Dietl, Myriame Abou Mrad, et al.

Selected by 01 December 2025

Jawdat Sandakly

Developmental Biology

Gut microbial composition modulates food-specific CD4+ T cells in food allergy

Alexa R Weingarden, Flannery S Dahlberg, Caroline N Broude, et al.

Selected by 28 November 2025

Mitchell Sarmie, Serena Restori

Immunology

ROCK2 inhibition has a dual role in reducing ECM remodelling and cell growth, while impairing migration and invasion

Daniel A. Reed, Anna E. Howell, Nadia Kuepper, et al.

Selected by 27 November 2025

Sharvari Pitke

Cancer Biology
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Latest spotLight

spotLights is an interview series dedicated to highlighting exciting new preprints in the biological sciences and the early-career researchers driving the work.

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Preprints by preLighters: Hala Taha

Every research paper carries a story—one that rarely makes it into the methods or the discussion section. Mine begins in a small parasitology lab in Sudan, on the last day before the war forced me to flee. That morning, a photo was taken of me and a colleague as we…

Posted on 24 November 2025

preLighting with a little help from AI

Written by: Reinier Prosée, preLights Community Manager Note: this post got a little help from Microsoft Copilot to keep things clear and to-the-point. Writing is perhaps more an art than a science, something I realised while co-moderating a creative workshop on science communication earlier this year. This is not to…

Posted on 17 November 2025

preLighters go live! This Thursday

- How do membrane actin protrusions initiate T-cells signalling? - What does RhoA have to do with nuclear envelope tensions in stem cells? - Does advanced microscopy help study mechano-signalling - and how? - Why did the authors decide to preprint their research?   Welcome to our September mix of…

Posted on 1 September 2025

Recent preLists

October in preprints – DevBio & Stem cell biology

Each month, preLighters with expertise across developmental and stem cell biology nominate a few recent developmental and stem cell biology (and related) preprints they’re excited about and explain in a single paragraph why. Short, snappy picks from working scientists — a quick way to spot fresh ideas, bold methods and papers worth reading in full. These preprints can all be found in the October preprint list published on the Node.

 



List by Deevitha Balasubramanian et al.

October in preprints – Cell biology edition

Different preLighters, with expertise across cell biology, have worked together to create this preprint reading list for researchers with an interest in cell biology. This month, most picks fall under (1) Cell organelles and organisation, followed by (2) Mechanosignaling and mechanotransduction, (3) Cell cycle and division and (4) Cell migration

 



List by Matthew Davies et al.

September in preprints – Cell biology edition

A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading list. This month, categories include: (1) Cell organelles and organisation, (2) Cell signalling and mechanosensing, (3) Cell metabolism, (4) Cell cycle and division, (5) Cell migration

 



List by Sristilekha Nath et al.

August in preprints – Cell biology edition

A group of preLighters, with expertise in different areas of cell biology, have worked together to create this preprint reading list for researchers with an interest in cell biology. This month, categories include: (1) Cancer biology (2) Mechanosignaling and mechanotransduction (3) Cell organelles and organisation

 



List by Vibha SINGH, Matthew Davies
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