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Inference of drug off-target effects on cellular signaling using Interactome-Based Deep Learning

Nikolaos Meimetis, Douglas A. Lauffenburger, Avlant Nilsson

The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity

Hasan Mamar, Roberta Fajka-Boja, Mónika Mórocz, et al.

Digitize your Biology! Modeling multicellular systems through interpretable cell behavior

Jeanette A.I. Johnson, Genevieve L. Stein-O’Brien, Max Booth, et al.

Discussion

NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections

Björn Klabunde, André Wesener, Wilhelm Bertrams, et al.

NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis

Hayden T. Pacl, Krishna C. Chinta, Vineel P. Reddy, et al.

Mentoring practices predictive of doctoral student outcomes in a biological sciences cohort

Reena Debray, Emily A. Dewald-Wang, Katherine K. Ennis

The landscape of biomedical research

Rita González-Márquez, Luca Schmidt, Benjamin M. Schmidt, et al.

AND

ChatGPT identifies gender disparities in scientific peer review

Jeroen P.H. Verharen

VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis

Fatima Rizvi, Yu-Ri Lee, Ricardo Diaz-Aragon, et al.

Subchronic alteration of vestibular hair cells in mice: implications for multisensory gaze stabilization

Louise Schenberg, Aïda Palou, François Simon, et al.

Discovery and Validation of Context-Dependent Synthetic Mammalian Promoters

Adam M. Zahm, William S. Owens, Samuel R. Himes, et al.

Planarians employ diverse and dynamic stem cell microenvironments to support whole-body regeneration

Blair W. Benham-Pyle, Frederick G. Mann Jr., Carolyn E. Brewster, et al.

Discussion

Caveola mechanotransduction reinforces the cortical cytoskeleton to promote epithelial resilience

John W. Brooks, Vikas Tillu, Suzie Verma, et al.