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Combinatorial and Inducible CRISPRa/i Enables Canalized hiPSC Forward Programming and Iterative Refinement via Single-Cell genomics

Federica Sozza, Alberto Romano, Nicole D’Elia, et al.

Inhibition of the gut ceramidase Asah2 decelerates the vertebrate ageing rate

Ayami Takaochi, Kota Abe, Yuki Sugiura, et al.

Discussion

DNA Specimen Preservation using DESS and DNA Extraction in Museum Collections: A Case Study Report

Eri Ogiso-Tanaka, Daisuke Shimada, Akito Ogawa, et al.

Kosmos: An AI Scientist for Autonomous Discovery

Ludovico Mitchener, Angela Yiu, Benjamin Chang, et al.

Discussion

A high-coverage genome from a 200,000-year-old Denisovan

Stéphane Peyrégne, Diyendo Massilani, Yaniv Swiel, et al.

AND

A global map for introgressed structural variation and selection in humans

PingHsun Hsieh, Natthapon Soisangwan, David S. Gordon, et al.

Beyond venomous fangs: Uloboridae spiders have lost their venom but not their toxicity

Xiaojing Peng, Ludwig Dersch, Josephine Dresler, et al.

Environmental and Maternal Imprints on Infant Gut Metabolic Programming

Kine Eide Kvitne, Celeste Allaband, Jennifer C. Onuora, et al.

Discussion

STEAMBOAT: Attention-based multiscale delineation of cellular interactions in tissues

Shaoheng Liang, Junjie Tang, Guanghan Wang, et al.

Discussion

Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility

Kate E. McCluskey, Katherine M. Stovell, Karen Law, et al.

Enhancer cooperativity can compensate for loss of activity over large genomic distances

Henry Thomas, Songjie Feng, Marie Huber, et al.

Characterization of natural product inhibitors of quorum sensing in Pseudomonas aeruginosa reveals competitive inhibition of RhlR by ortho-vanillin

Kathryn E. Woods, Sana Akhter, Blanca Rodriguez, et al.

Discussion

Fetal brain response to maternal inflammation requires microglia

Bridget Elaine LaMonica Ostrem, Nuria Dominguez Iturza, Jeffrey Stogsdill, et al.

Discussion