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A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic

Maria Alimova, Eriene-Heidi Sidhom, Abhigyan Satyam, et al.

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Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses

Willianne Hoepel, Hung-Jen Chen, Sona Allahverdiyeva, et al.

An Atlas of Gene Regulatory Elements in Adult Mouse Cerebrum

Yang Eric Li, Sebastian Preissl, Xiaomeng Hou, et al.

Single-cell longitudinal analysis of SARS-CoV-2 infection in human bronchial epithelial cells

Neal G. Ravindra, Mia Madel Alfajaro, Victor Gasque, et al.

Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes

Jiwen Li, Lin Pan, Marlesa I. Godoy, et al.

Conflicts with diarrheal pathogens trigger rapid evolution of an intestinal signaling axis

Clayton M. Carey, Sarah E. Apple, Zoё A. Hilbert, et al.

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

David E. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, et al.

The WD and linker domains of ATG16L1 required for non-canonical autophagy limit lethal influenza A virus infection at epithelial surfaces

Yingxue Wang, Weijiao Zhang, Matthew Jefferson, et al.

Hypoxia induces transcriptional and translational downregulation of the type I interferon (IFN) pathway in multiple cancer cell types

Ana Miar, Esther Arnaiz, Esther Bridges, et al.

TGFβ restricts T cell function and bacterial control within the tuberculous granuloma

Benjamin H Gern, Kristin N Adams, Courtney R Plumlee, et al.

Tousled-like kinase activity is required for transcriptional silencing and suppression of innate immune signaling

Sandra Segura-Bayona, Marina Villamor-Payà, Camille Stephan-Otto Attolini, et al.

AGO1x prevents dsRNA-induced interferon signaling to promote breast cancer cell proliferation

Souvik Ghosh, Joao C Guimaraes, Manuela Lanzafame, et al.

Human DNA-PK activates a STING-independent DNA sensing pathway

Katelyn Burleigh, Joanna H. Maltbaek, Stephanie Cambier, et al.