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A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

David E. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, et al.

The WD and linker domains of ATG16L1 required for non-canonical autophagy limit lethal influenza A virus infection at epithelial surfaces

Yingxue Wang, Weijiao Zhang, Matthew Jefferson, et al.

Hypoxia induces transcriptional and translational downregulation of the type I interferon (IFN) pathway in multiple cancer cell types

Ana Miar, Esther Arnaiz, Esther Bridges, et al.

Discussion

TGFβ restricts T cell function and bacterial control within the tuberculous granuloma

Benjamin H Gern, Kristin N Adams, Courtney R Plumlee, et al.

Discussion

Tousled-like kinase activity is required for transcriptional silencing and suppression of innate immune signaling

Sandra Segura-Bayona, Marina Villamor-Payà, Camille Stephan-Otto Attolini, et al.

Discussion

AGO1x prevents dsRNA-induced interferon signaling to promote breast cancer cell proliferation

Souvik Ghosh, Joao C Guimaraes, Manuela Lanzafame, et al.

Human DNA-PK activates a STING-independent DNA sensing pathway

Katelyn Burleigh, Joanna H. Maltbaek, Stephanie Cambier, et al.

Discussion

Evolution-guided design of super-restrictor antiviral proteins reveals a breadth-versus-specificity tradeoff

Rossana S Colon-Thillet, Emily S Hsieh, Laura Graf, et al.

Discussion

SLC19A1 is a cyclic dinucleotide transporter

Rutger Luteijn, Shivam Zaver, Benjamin G Gowen, et al.

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SLC19A1 is an importer of the immunotransmitter cGAMP

Anthony F. Cordova, Christopher Ritchie, Gaelen T. Hess, et al.

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2'3'-cGAMP is an immunotransmitter produced by cancer cells and regulated by ENPP1

Jacqueline A Carozza, Volker Boehnert, Kelsey E Shaw, et al.

Discussion

RNase L reprograms translation by widespread mRNA turnover escaped by antiviral mRNAs

James M Burke, Stephanie L Moon, Evan T Lester, et al.

Discussion

An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics

Ilias Angelidis, Lukas M Simon, Isis E Fernandez, et al.