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MechanoMaST – a multimodal pipeline for spatially registering mechanical and transcriptomic tissue data

Linda Decker, Dmitrii Olisov, Nikolai Schleußner, et al.

AND

Paired-surface spatial mechanomics links tissue stiffness maps to spatial transcriptomics

Huan Ting Ong, Yuting Lou, Jake Turley, et al.

Midgestation metabolic constraint in purine metabolism drives distinct strategies for placenta and fetal growth

Weizhi Xu, Nancy De La Cruz, Andrea Woods, et al.

Discussion

Inhibition of the gut ceramidase Asah2 decelerates the vertebrate ageing rate

Ayami Takaochi, Kota Abe, Yuki Sugiura, et al.

Discussion

A potential anti-amyloidogenic therapy for type 2 diabetes based on the QBP1 peptide

María M. Tejero-Ojeda, Ada Bernaus Vives, Michal Wojciechowski, et al.

Discussion

Small Molecule Agonists of TREM2 Reprogram Microglia and Protect Synapses in Human Alzheimer’s Models

Hossam Nada, Shaoren Yuan, Farida El Gaamouch, et al.

The lipidomic architecture of the mouse brain

Luca Fusar Bassini, Halima Hannah Schede, Laura Capolupo, et al.

Discussion

Kosmos: An AI Scientist for Autonomous Discovery

Ludovico Mitchener, Angela Yiu, Benjamin Chang, et al.

Discussion

Mitochondrial Fatty Acid Oxidation is Stimulated by Red Light Irradiation

Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Mauricio S. Baptista, et al.

Discussion

Microbial Feast or Famine: dietary carbohydrate composition and gut microbiota metabolic function

Blake Dirks, Alex E. Mohr, Karen D. Corbin, et al.

Discussion

Vitamin B12 supports skeletal muscle oxidative phosphorylation capacity in male mice

Luisa F. Castillo, Katarina E. Heyden, Abigail R. Williamson, et al.

Discussion

Aspartate transaminases are required for blood development

Narges Pourmandi, Greggory Myers, Arjun Jha, et al.

In vitro pharmacokinetics and pharmacodynamics of the diarylquinoline TBAJ-587 and its metabolites against Mycobacterium tuberculosis

Diana Angelica Aguilar-Ayala, Marie Sylvianne Rabodoarivelo, Maxime R. Eveque-Mourroux, et al.