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Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain

Fani Pantouli, Travis W. Grim, Cullen L. Schmid, et al.

SF3B1-targeted Splicing Inhibition Triggers Global Alterations in Transcriptional Dynamics and R-Loop Metabolism

Daisy Castillo-Guzman, Stella R. Hartono, Lionel A. Sanz, et al.

Live-cell imaging shows uneven segregation of extrachromosomal DNA elements and transcriptionally active extrachromosomal DNA clusters in cancer

Eunhee Yi, Amit D. Gujar, Molly Guthrie, et al.

Hydroxychloroquine increased psychiatric-like behaviors and disrupted the expression of related genes in the mouse brain

H Xu, XY Zhang, WW Wang, et al.

Pseudouridine synthases modify human pre-mrna co-transcriptionally and affect splicing

Functional diversification of Ser-Arg rich protein kinases to control ubiquitin-dependent neurodevelopmental signalling

Francisco Bustos, Anna Segarra-Fas, Gino Nardocci, et al.

PACAP induces light aversion in mice by an inheritable mechanism independent of CGRP

Adisa Kuburas, Bianca N. Mason, Benjamin Hing, et al.

Ana1 recruits PLK1 to mother centrioles to promote mitotic PCM assembly and centriole elongation

Ines Alvarez-Rodrigo, Alan Wainman, Jordan W. Raff

Optoribogenetic control of regulatory RNA molecules

Sebastian Pilsl, Charles Morgan, Moujab Choukeife, et al.

A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic

Maria Alimova, Eriene-Heidi Sidhom, Abhigyan Satyam, et al.

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Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses

Willianne Hoepel, Hung-Jen Chen, Sona Allahverdiyeva, et al.

Increased SGK1 activity potentiates mineralocorticoid/NaCl-induced hypertension and kidney injury

Catalina Sierra-Ramos, Silvia Velazquez-Garcia, Ayse G. Keskus, et al.

Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure

Jerome AJ Becker, Lucie P Pellissier, Yannick Corde, et al.