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Trade-offs between surviving and thriving: A careful balance of physiological limitations and reproductive effort under thermal stress

David Hubert, Ehren Bentz, Robert T Mason

Discussion

Snake venom metalloproteinases are predominantly responsible for the cytotoxic effects of certain African viper venoms

Keirah E. Bartlett, Adam Westhorpe, Mark C. Wilkinson, et al.

KANK2 at focal adhesion regulates their maintenance and dynamics, while at fibrillar adhesions it influences cell migration via microtubule-dependent mechanism

Nikolina Stojanović, Anja Rac, Marija Lončarić, et al.

Cryo-EM reveals multiple mechanisms of ribosome inhibition by doxycycline

William S. Stuart, Michail N. Isupov, Mathew McLaren, et al.

Enzymatic bromination of native peptides for late-stage structural diversification via Suzuki-Miyaura coupling

Haley N. Bridge, Chase L. Radziej, Amy M. Weeks

Discussion

PIP5K-Ras bistability triggers plasma membrane symmetry breaking to define cellular polarity and regulate migration

Yu Deng, Tatsat Banerjee, Satomi Matsuoka, et al.

Junctional Heterogeneity Shapes Epithelial Morphospace

Anubhav Prakash, Raman Kaushik, Nishant Singh, et al.

Loss of MGST1 during fibroblast differentiation enhances vulnerability to oxidative stress in human heart failure

Mohamad Youness, Onne A.H.O. Ronda, Ankit Pradhan, et al.

Discussion

Imaging cellular activity simultaneously across all organs of a vertebrate reveals body-wide circuits

Virginia M. S. Ruetten, Wei Zheng, Igor Siwanowicz, et al.

Microbial Feast or Famine: dietary carbohydrate composition and gut microbiota metabolic function

Blake Dirks, Alex E. Mohr, Karen D. Corbin, et al.

Discussion

Vitamin B12 supports skeletal muscle oxidative phosphorylation capacity in male mice

Luisa F. Castillo, Katarina E. Heyden, Abigail R. Williamson, et al.

Discussion

A high-coverage genome from a 200,000-year-old Denisovan

Stéphane Peyrégne, Diyendo Massilani, Yaniv Swiel, et al.

AND

A global map for introgressed structural variation and selection in humans

PingHsun Hsieh, Natthapon Soisangwan, David S. Gordon, et al.

Discussion