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Foldamers Reveal and Validate Novel Therapeutic Targets Associated with Toxic α-synuclein Self-Assembly

Jemil Ahmed, Tessa C. Fitch, Courtney M. Donnelly, et al.

Selected by Joanna Zell

Novel insights in the pathophysiology of α-synuclein dysregulation on D2 receptor activity contributing to the vulnerability of dopamine neurons

Abeer Dagra, Douglas R. Miller, Fatemeh Shaerzadeh, et al.

Selected by Emma Wilson

Selectivity of Protein Interactions along the Aggregation Pathway of α-synuclein

André D. G. Leitão, Paulina Rudolffi Soto, Alexandre Chappard, et al.

Selected by Utrecht Protein Folding and Assembly

CSPα reduces aggregates and rescues striatal dopamine release in αsynuclein transgenic mice

L Caló, E Hidari, M Wegrzynowicz, et al.

Selected by Kristina Kuhbandner

In situ architecture of neuronal α-synuclein inclusions

Victoria A. Trinkaus, Irene Riera-Tur, Antonio Martínez-Sánchez, et al.

Selected by Tessa Sinnige

FUS gene is dual-coding with both proteins united in FUS-mediated toxicity

Marie A. Brunet, Jean-Francois Jacques, Sonya Nassari, et al.

Selected by Madhuja Samaddar

Skd3 (human CLPB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations

Ryan R. Cupo, James Shorter

Selected by Tessa Sinnige

Selective K-ATP channel-dependent loss of pacemaking in vulnerable nigrostriatal dopamine neurons by α-synuclein aggregates

Poonam Thakur, Kelvin Luk, Jochen Roeper

Selected by Jessica Xie

HSP110 dependent HSP70 disaggregation machinery mediates prion-like propagation of amyloidogenic proteins in metazoa

Jessica Tittelmeier, Carl Alexander Sandhof, Heidrun Maja Ries, et al.

Selected by Tessa Sinnige

The properties of α-synuclein secondary nuclei are dominated by the solution conditions rather than the seed fibril strain

Alessia Peduzzo, Sara Linse, Alexander K. Buell

Selected by Tessa Sinnige

Negative Regulation of Autophagy by UBA6-BIRC6–Mediated Ubiquitination of LC3

Rui Jia, Juan S. Bonifacino

Selected by Sandra Malmgren Hill

A non-canonical arm of UPR^ER mediates longevity through ER remodeling and lipophagy.

Joseph R Daniele, Ryo Higuchi-Sanabria, Vidhya Ramachandran, et al.

Selected by Sandra Franco Iborra