Microtubules form by progressively faster tubulin accretion, not by nucleation-elongation
This study models and investigates the poorly understood, very early steps of microtubule nucleation. It provides the surprising insight that this polymer likely assembles in layers and not by the addition of single monomer units.
Soluble tubulin is locally enriched at mitotic centrosomes in C. elegans
This preprint uses imaging techniques to demonstrate that compared to the rest of the cytosol, soluble and polymeric tubulin concentration is dramatically increased around the poles of a dividing cell when 1000s of microtubules are being built to generate a mitotic spindle. Future work should address how such high concentrations are maintained!
Posted on: 20th May 2019 , updated on: 21st May 2019