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Phase separation

A preprint list to follow the burgeoning field of phase separation in biological processes.

List by Angika Basant

Preprints:

Endocytosis caused by liquid-liquid phase separation of proteins

Louis-Philippe Bergeron-Sandoval, Hossein Khadivi Heris, Catherine Chang, Caitlin E. Cornell, Sarah L. Keller, Paul François, Adam G. Hendricks, Allen J. Ehrlicher, Rohit V. Pappu, Stephen W. Michnick

https://www.biorxiv.org/content/10.1101/145664v3?%3Fcollection=

This preprint shows that some proteins involved in clathrin-mediated endocytosis contain prion-like domains that allow formation of biomolecular condensates of these complexes. Their data also suggests that such condensates may be able to perform important mechanical functions such as deforming the plasma membrane.

The Glycolytic Protein Phosphofructokinase Dynamically Relocalizes into Subcellular Compartments with Liquid-like Properties in vivo

SoRi Jang, Zhao Xuan, Ross C. Lagoy, Louise M. Jawerth, Ian Gonzalez, Milind Singh, Shavanie Prashad, Hee Soo Kim, Avinash Patel, Dirk R. Albrecht, Anthony A. Hyman, Daniel A. Colón-Ramos

https://www.biorxiv.org/content/10.1101/636449v1

Contrary to a textbook notion of soluble, homogenous metabolic enzymes, a previous study (Webb et al., 2017) showed that a human liver isoform of the glycolytic enzyme phosphofructokinase (PFK) can assemble into filaments in vitro. This preprint demonstrates that PFK has a distinct sub-cellular organisation in C. elegans muscle and can form transient, phase separated condensates in C. elegans neurons.

 

Posted on: 4th June 2019

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