During my PhD with Arno Müller (University of Düsseldorf, Germany / University of Dundee, UK) I worked on cell migration and cell shape changes during Drosophila gastrulation. In particular, I focused on the role of a multi-functional guanine nucleotide exchange factor which is an essential regulator of small GTPases during cytokinesis and the fibroblast growth factor-triggered mesoderm migration in the Drosophila gastrula.
In the past few years as a postdoc in the lab of Stefan Schulte-Merker (initially Hubrecht Institute Utrecht, Netherlands and currently University of Münster, Germany) I continued to work on cell motility, cell-cell communication and the underlying developmental programs that orchestrate organogenesis but this time with a special focus on the formation and maturation of the blood and lymphatic vascular system. To visualize these processes in vivo, I am employing the zebrafish model which enables me to combine the power of in vivo imaging with the constantly growing genetic toolkit that allows the identification and characterization of new players controlling the behavior of different endothelial subpopulations during zebrafish development.
Besides my strong interest in vascular biology I am also interested in newly emerging techniques like the CRISPR/Cas9 system and its derivatives that in the past years completely revolutionized the approaches and possibilities not only in zebrafish research.
Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons
A metabolic switch from OXPHOS to glycolysis is essential for cardiomyocyte proliferation in the regenerating heart
Arterio-Venous Remodeling in the Zebrafish Trunk Is Controlled by Genetic Programming and Flow-Mediated Fine-Tuning
mRNA localisation in endothelial cells regulates blood vessel sprouting
Genetic compensation is triggered by mutant mRNA degradation