I am a cell and developmental biologist currently working as a post-doctoral research fellow in Clare Waterman’s group at National Institutes of Health, Bethesda USA. I am interested in the spatial organization and patterning of signaling components on the plasma membrane and how signaling dynamics regulate downstream cytoskeletal processes. I am currently looking at the bleb-based migration under low adhesion and high confinement in melanoma metastatic cells. I am curious about how metastatic cells remain polarized while moving under different extra-cellular matrix conditions?
During my PhD, I worked under the mentorship of Thomas Lecuit in Marseille France and in collaboration with Satyajit Mayor in NCBS, Bangalore India to work on the interface of membrane organization of signaling components on the plasma membrane regulating mechanics during gastrulation. I was curious to understand molecular basis of germ-band extension, which is one of the key morphogenetic events during gastrulation. To understand this, I did quantitative measurements of receptor-ligand interactions on the plasma membrane by using fluorescence correlation spectroscopy (FCS) and reported activation of receptor by measuring receptor cluster formation in vivo. I also reported the importance of de-sensitization pathway and endocytosis on receptor signaling from the plasma membrane. I proposed a mechanism of dynamic modulation and arrangement of receptors on the membrane regulating quantitative Rho-Rok signaling during cell shape changes in gastrulation.
Osmolarity-independent electrical cues guide rapid response to injury in zebrafish epidermis
Glycocalyx-mediated Cell Adhesion and Migration
Podoplanin drives dedifferentiation and amoeboid invasion of melanoma
A flagellate-to-amoeboid switch in the closest living relatives of animals
Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments
Direct Arp2/3-vinculin binding is essential for cell spreading, but only on compliant substrates and in 3D
Snail induces epithelial cell extrusion through transcriptional control of RhoA contractile signaling and cell matrix adhesion
Oncogenic signaling alters cell shape and mechanics to facilitate cell division under confinement
CellBio 2022 – An ASCB/EMBO Meeting
This preLists features preprints that were discussed and presented during the CellBio 2022 meeting in Washington, DC in December 2022.
|List by||Nadja Hümpfer et al.|
ASCB | EMBO Cell Bio *virtual* 2020
Preprints + open discussions related to work presented at Cell Bio 2020 in December
|List by||Dey Lab et al.|
Preprints and open discussions related to cell migration. Includes preprints discussed in online cell migration seminar series.
|List by||Ankita Jha|