Skd3 (human CLPB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations
Selected by
Tessa Sinnige
Selective K-ATP channel-dependent loss of pacemaking in vulnerable nigrostriatal dopamine neurons by α-synuclein aggregates
Selected by
Jessica Xie
HSP110 dependent HSP70 disaggregation machinery mediates prion-like propagation of amyloidogenic proteins in metazoa
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Tessa Sinnige
The properties of α-synuclein secondary nuclei are dominated by the solution conditions rather than the seed fibril strain
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Tessa Sinnige
Negative Regulation of Autophagy by UBA6-BIRC6–Mediated Ubiquitination of LC3
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Sandra Malmgren Hill
Elucidating the molecular determinants of Aβ aggregation with deep mutational scanning
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Suzanne McDermott
A non-canonical arm of UPRER mediates longevity through ER remodeling and lipophagy.
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Sandra Franco Iborra
Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain (AL) amyloidosis patient
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Tessa Sinnige