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Inference of drug off-target effects on cellular signaling using Interactome-Based Deep Learning

Nikolaos Meimetis, Douglas A. Lauffenburger, Avlant Nilsson

Selected by Benjamin Dominik Maier

Mechano-dependent sorbitol accumulation supports biomolecular condensate

Stephanie Torrino, William M Oldham, Andrés R Tejedor, et al.

Selected by Teodora Piskova

Glial Draper signaling triggers cross-neuron plasticity in bystander neurons after neuronal cell death

Yupu Wang, Ruiling Zhang, Sihao Huang, et al.

Selected by Matthew Davies

Regeneration leads to global tissue rejuvenation in aging sexual planarians

Xiaoting Dai, Xinghua Li, Scott Pletcher, et al.

Selected by Sophia Friesen

DNA methylation rates scale with maximum lifespan across mammals

Samuel. J. C. Crofts, Eric Latorre-Crespo, Tamir Chandra

Selected by Jennifer Ann Black

Sub-lethal apoptotic stress enables mtDNA release during senescence and drives the SASP

James Chapman, Hanna Salmonowicz, Stella Victorelli, et al.

Selected by Roberto Amadio

Local IL-17 orchestrates skin aging

Paloma Solá, Elisabetta Mereu, Júlia Bonjoch, et al.

Selected by Andrea Irazoki

ageing-associated myelin dysfunction drives amyloid deposition in mouse models of Alzheimer’s disease

Constanze Depp, Ting Sun, Andrew Octavian Sasmita, et al.

Selected by Kristina Kuhbandner

Astrocyte plasticity ensures continued endfoot coverage of cerebral blood vessels and integrity of the blood brain barrier, with plasticity declining with normal aging

William A. Mills III, Shan Jiang, Joelle Martin, et al.

Selected by Ranabir Chakraborty

Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth

Suprit Gupta, Julian Yano, Htet Htwe Htwe, et al.

Selected by Berrak Ugur

Intercellular telomere transfer extends T cell lifespan

Bruno Vaz, Claudia Vuotto, Salvatore Valvo, et al.

Selected by Giuseppina D'Alessandro

Epigenetic conflict on a degenerating Y chromosome increases mutational burden in Drosophila males

Kevin H.-C. Wei, Lauren Gibilisco, Doris Bachtrog

Selected by Hann Ng