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Short N-terminal disordered regions and the proline-rich domain are major regulators of phase transitions for full-length UBQLN1, UBQLN2 and UBQLN4

Thuy P. Dao, Anitha Rajendran, Sarasi K. K. Galagedera, et al.



Selected by Aniruddha Das

VAP spatially stabilizes dendritic mitochondria to locally fuel synaptic plasticity

Ojasee Bapat, Tejas Purimetla, Sarah Kruessel, et al.



Selected by Kritika Mehta

Motion of single molecular tethers reveals dynamic subdomains at ER-mitochondria contact sites

Christopher J. Obara, Jonathon Nixon-Abell, Andrew S. Moore, et al.



Selected by Holly Smith

A copper chaperone-mimetic polytherapy for SOD1-associated amyotrophic lateral sclerosis

McAlary L., Shephard V.K., Wright G.S.A., et al.



Selected by Utrecht Protein Folding and Assembly

Microglia become hypofunctional and release metalloproteases and tau seeds after phagocytosing live neurons with P301S tau aggregates

Jack H. Brelstaff, Matthew Mason, Taxiarchis Katsinelos, et al.



Selected by Kristina Kuhbandner

FUS-dependent liquid-liquid phase separation is an early event in double-strand break repair

Brunno R. Levone, Silvia C. Lenzken, Marco Antonaci, et al.



Selected by Sree Rama Chaitanya, Giuseppina D'Alessandro

Decoding distinctive features of plasma extracellular vesicles in amyotrophic lateral sclerosis

Laura Pasetto, Stefano Callegaro, Deborah Ferrara, et al.



Selected by Kristina Kuhbandner

amyotrophic lateral sclerosis associated mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex

MS Dyer, KE Lewis, AK Walker, et al.



Selected by Kristina Kuhbandner

FUS gene is dual-coding with both proteins united in FUS-mediated toxicity

Marie A. Brunet, Jean-Francois Jacques, Sonya Nassari, et al.



Selected by Madhuja Samaddar

Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease

Richard J. Wheeler, Hyun O. Lee, Ina Poser, et al.



Selected by Madhuja Samaddar

Generalized displacement of DNA- and RNA-binding factors mediates the toxicity of arginine-rich cell-penetrating peptides

V. Lafarga, O. Sirozh, I. Díaz-López, et al.



Selected by Emily Graves

Molecularly distinct cores coexist inside stress granules

Luca Cirillo, Adeline Cieren, Monica Gotta



Selected by Tessa Sinnige

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