The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to brca1-independent PARP inhibitor sensitivity
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14 November 2023
Audrey Noireterre
![Cancer Biology Cancer Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/cancer-biology.png)
Polθ is phosphorylated by Polo-like kinase 1 (PLK1) to enable repair of DNA double strand breaks in mitosis
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05 June 2023
Pierre Caron
![Molecular Biology Molecular Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/molecular-biology.png)
EXO1-mediated DNA repair by single-strand annealing is essential for brca1-deficient cells
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15 May 2023
Jennifer Ann Black
![Molecular Biology Molecular Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/molecular-biology.png)
brca1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote replication fork stability and continuous DNA synthesis
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09 March 2023
Pierre Caron
![Cancer Biology Cancer Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/cancer-biology.png)
Nuclear myosin VI maintains replication fork stability
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13 December 2022
Pierre Caron
![Molecular Biology Molecular Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/molecular-biology.png)
Pin1-promoted SUMOylation of RNF168 restrains its chromatin accumulation
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20 June 2022
Pierre Caron
![Biochemistry Biochemistry](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/biochemistry.png)
Saturation variant interpretation using CRISPR prime editing
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20 October 2021
Jeffrey Calhoun
![Genetics Genetics](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/genetics.png)
Two redundant ubiquitin-dependent pathways of brca1 localization to DNA damage sites
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10 August 2021
Giuseppina D'Alessandro
![Cell Biology Cell Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/cell-biology.png)
FUS-dependent liquid-liquid phase separation is an early event in double-strand break repair
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05 February 2021
Sree Rama Chaitanya, Giuseppina D'Alessandro
![Cell Biology Cell Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/cell-biology.png)
EccDNA formation is dependent on MMEJ, repressed by c-NHEJ pathway, and stimulated by DNA double-strand break
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05 January 2021
Sree Rama Chaitanya
![Cancer Biology Cancer Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/cancer-biology.png)
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination deficient cells
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31 December 2020
Giuseppina D'Alessandro
![Cancer Biology Cancer Biology](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/cancer-biology.png)
Aberrant replication licensing drives Copy Number Gains across species
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12 October 2020
Yasmin Lau
![Genetics Genetics](https://prelights.biologists.com/wp-content/themes/thecobpph/assets/images/categories/transparent-no-type/genetics.png)