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The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to brca1-independent PARP inhibitor sensitivity

Hasan Mamar, Roberta Fajka-Boja, Mónika Mórocz, et al.

Selected by 14 November 2023

Audrey Noireterre

Cancer Biology

Polθ is phosphorylated by Polo-like kinase 1 (PLK1) to enable repair of DNA double strand breaks in mitosis

Camille Gelot, Marton Tibor Kovacs, Simona Miron, et al.

Selected by 05 June 2023

Pierre Caron

Molecular Biology

EXO1-mediated DNA repair by single-strand annealing is essential for brca1-deficient cells

B. van de Kooij, A. Schreuder, R.S. Pavani, et al.

Selected by 15 May 2023

Jennifer Ann Black

Molecular Biology

brca1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote replication fork stability and continuous DNA synthesis

Daniel Salas-Lloret, Néstor García-Rodríguez, Lisanne Giebel, et al.

Selected by 09 March 2023

Pierre Caron

Cancer Biology

Nuclear myosin VI maintains replication fork stability

Jie Shi, Kristine Hauschulte, Ivan Mikicic, et al.

Selected by 13 December 2022

Pierre Caron

Molecular Biology

Pin1-promoted SUMOylation of RNF168 restrains its chromatin accumulation

Anoop Singh Chauhan, Alexander J. Garvin, Mohammed Jamshad, et al.

Selected by 20 June 2022

Pierre Caron

Biochemistry

Saturation variant interpretation using CRISPR prime editing

Steven Erwood, Teija M.I. Bily, Jason Lequyer, et al.

Selected by 20 October 2021

Jeffrey Calhoun

Genetics

Two redundant ubiquitin-dependent pathways of brca1 localization to DNA damage sites

Alana Sherker, Natasha Chaudhary, Salomé Adam, et al.

Selected by 10 August 2021

Giuseppina D'Alessandro

Cell Biology

FUS-dependent liquid-liquid phase separation is an early event in double-strand break repair

Brunno R. Levone, Silvia C. Lenzken, Marco Antonaci, et al.

Selected by 05 February 2021

Sree Rama Chaitanya, Giuseppina D'Alessandro

Cell Biology

EccDNA formation is dependent on MMEJ, repressed by c-NHEJ pathway, and stimulated by DNA double-strand break

Teressa Paulsen, Pumoli Malapati, Rebeka Eki, et al.

Selected by 05 January 2021

Sree Rama Chaitanya

Cancer Biology

ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination deficient cells

Priyanka Verma, Yeqiao Zhou, Zhendong Cao, et al.

Selected by 31 December 2020

Giuseppina D'Alessandro

Cancer Biology

Aberrant replication licensing drives Copy Number Gains across species

Patroula Nathanailidou, Michalis Petropoulos, Styliani Maxouri, et al.

Selected by 12 October 2020

Yasmin Lau

Genetics
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