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IMMClock reveals immune aging and T cell function at single-cell resolution

Yael Gurevich Schmidt, Di Wu, Sanna Madan, et al.

Adenine DNA methylation associated to transcription is widespread across eukaryotes

Pedro Romero Charria, Cristina Navarrete, Vladimir Ovchinnikov, et al.

Deep learning-based predictions of gene perturbation effects do not yet outperform simple linear methods

Constantin Ahlmann-Eltze, Wolfgang Huber, Simon Anders

A fine kinetic balance of interactions directs transcription factor hubs to genes

Apratim Mukherjee, Samantha Fallacaro, Puttachai Ratchasanmuang, et al.

Cell cycle-dependent mRNA localization in P-bodies

Adham Safieddine, Marie-Noëlle Benassy, Thomas Bonte, et al.

Discussion

Modular control of time and space during vertebrate axis segmentation

Ali Seleit, Ian Brettell, Tomas Fitzgerald, et al.

AND

Natural genetic variation quantitatively regulates heart rate and dimension

Jakob Gierten, Bettina Welz, Tomas Fitzgerald, et al.

Enhancer cooperativity can compensate for loss of activity over large genomic distances

Henry Thomas, Songjie Feng, Marie Huber, et al.

LINC complex alterations are a hallmark of sporadic and familial ALS/FTD

Riccardo Sirtori, Michelle Gregoire, Emily Potts, et al.

Temporal constraints on enhancer usage shape the regulation of limb gene transcription

Raquel Rouco, Antonella Rauseo, Guillaume Sapin, et al.

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

Hugo Sepulveda, Xiang Li, Xiaojing Yue, et al.

Discussion

Transcriptional profiling of human brain cortex identifies novel lncRNA-mediated networks dysregulated in amyotrophic lateral sclerosis

Alessandro Palma, Monica Ballarino

Discussion

Clusters of lineage-specific genes are anchored by ZNF274 in repressive perinucleolar compartments

Martina Begnis, Julien Duc, Sandra Offner, et al.