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Alzheimer’s Disease Patient Brain Extracts Induce Multiple Pathologies in Vascularized Neuroimmune Organoids for Disease Modeling and Drug Discovery

Yanru Ji, Xiaoling Chen, Meek Connor Joseph, et al.

Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility

Kate E. McCluskey, Katherine M. Stovell, Karen Law, et al.

Fetal brain response to maternal inflammation requires microglia

Bridget Elaine LaMonica Ostrem, Nuria Dominguez Iturza, Jeffrey Stogsdill, et al.

Discussion

A choroid plexus apocrine secretion mechanism shapes CSF proteome and embryonic brain development

Ya’el Courtney, Joshua P. Head, Elizabeth D. Yimer, et al.

Discussion

Single-cell epigenomic reconstruction of developmental trajectories in human neural organoid systems from pluripotency

Fides Zenk, Jonas Simon Fleck, Sophie Martina Johanna Jansen, et al.

Generating human neural diversity with a multiplexed morphogen screen in organoids

Neal D. Amin, Kevin W. Kelley, Jin Hao, et al.

A transposase-derived gene required for human brain development

Luz Jubierre Zapater, Elias Rodriguez-Fos, Merce Planas-Felix, et al.

CTCF is essential for proper mitotic spindle structure and anaphase segregation

Katherine Chiu, Yasmin Berrada, Nebiyat Eskndir, et al.

Stem cell-derived mouse embryos develop within an extra-embryonic yolk sac to form anterior brain regions and a beating heart

Gianluca Amadei, Charlotte E Handford, Joachim De Jonghe, et al.

AND

Mouse-embryo model derived exclusively from embryonic stem cells undergo neurulation and heart development

Kasey Y.C. Lau, Hernan Rubinstein, Carlos W. Gantner, et al.

Oligodendrocyte precursor cells engulf synaptic inputs in an experience- and microglia-dependent manner

Yohan S.S. Auguste, Austin Ferro, Jessica Dixon, et al.

Discussion

Defensive and offensive behaviors in social interaction settings in a Kleefstra syndrome mouse model

Alejandra Alonso, Anumita Samanta, Jacqueline van der Meij, et al.

Discussion

Young transposable elements rewired gene regulatory networks in human and chimpanzee hippocampal intermediate progenitors

Sruti Patoori, Samantha Barnada, Marco Trizzino