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AI semantics for biomedical data integration

James McLaughlin, Aleix Puig-Barbe, Arwa Ibrahim, et al.

Discussion

MechanoMaST – a multimodal pipeline for spatially registering mechanical and transcriptomic tissue data

Linda Decker, Dmitrii Olisov, Nikolai Schleußner, et al.

AND

Paired-surface spatial mechanomics links tissue stiffness maps to spatial transcriptomics

Huan Ting Ong, Yuting Lou, Jake Turley, et al.

Disrupting a Convergent Acetylation Circuit Collapses Leukemic Identity Across AML Subtypes

Anagha Deshpande, Cho-Ying Chiang, Marlenne Perales, et al.

Discussion

Combinatorial and Inducible CRISPRa/i Enables Canalized hiPSC Forward Programming and Iterative Refinement via Single-Cell Genomics

Federica Sozza, Alberto Romano, Nicole D’Elia, et al.

Site-Specific Inhibition of translation Initiation via 2’-O-methylation

Adam Suh, Stephanie Mou, Emmely A. Patrasso, et al.

Discussion

Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances chemotherapy efficacy in Ewing sarcoma

Alina Ritter, Malenka Zimmermann, Florian H. Geyer, et al.

Discussion

Dual inhibition of GTP-bound (ON) and GDP-bound (OFF) KRAS^G12C suppresses PI3Kα and leads to potent tumor inhibition

Katherine Parker, Samar Ghorbanpoor, Wafa Malik, et al.

Discussion

Ribosome Molecular Aging Shapes translation Dynamics

Jordy F. Botello, Lifei Jiang, Peter J. Metzger, et al.

Discussion

The metabolome and proteome of stem cell-derived human primordial germ cells: a multi-omics approach

Madalena Vaz Santos, Bauke V. Schomakers, Llobet Ayala Marta, et al.

Prenatal Stress Differentially Shapes Adult Behavior in Male and Female Offspring

Erbo Dong, Alison Chu, Tamar Gur, et al.

Discussion

UFMylation of Pyruvate Dehydrogenase Regulates Mitochondrial Metabolism

Phong T. Nguyen, Zheng Wu, Dohun Kim, et al.

Detergent-Triggered Membrane Remodelling Monitored via Intramembrane Fluorescence De-Quenching

Claudia M. F. Andrews, Christopher M. Hofmair, Lauryn Roberts, et al.

Discussion