Thanks to Emma for updating us on their recent episodes:
Episode 09: Incorrect Nucleotide Sequences are Unacceptably Frequent Within Scientific Literature
In episode 09 we discuss how published nucleotide sequences are not always correct or to be trusted with Yasunori Park and Professor Jennifer A Byrne, a research Assistant and PI at the University of Sydney. We delve into the details of their nifty new text mining tool (Blast and Seek) which highlights papers with incorrect nucleotide sequences. We discuss the most common mistakes found, the impact of these mistakes, and what we can do as researchers to prevent errors from occurring. We also talk about Preprints and Australian Research Council’s recent decision to ban preprints in their grant applications as well as some insight into our very own PhD projects.
Episode 10: Paywall: The business of Scholarship
In episode 10 we discuss the business of scholarship with Professor Jason Schmitt, Chair of Communication and Media at Clarkson University.
In 2018, UK universities spent over £210 million on publication costs (including access etc). This could have paid for; 700 ECR fellowships or 6500 postdocs or >8500 technicians or 3,500 PhDs (4yr fees + stipend). Meanwhile, Elsevier had profit margins of 37%. This week we discuss the broken publishing system and Jason’s documentary Paywall: The Business of Scholarship.
Episode 11: Laterally Transferred Macrophage Mitochondria Act As A Signalling Source Promoting Cancer Cell Proliferation
This week we discussed the transfer of mitochondria from macrophages to cancer cells with Dr Chelsea Kidwill & Joseph Casalin, Postdoctoral Research Associate and PhD student in the lab of Professor Minna Roh-Johnson at the University of Utah. We delve into why this transfer occurs, the mechanism of transfer, and how this impacts the recipient cells. We also speak to Joseph about his alternative schooling, in addition to our usual chat about the importance of preprints and our ideas for how to improve academia.
Episode 12: Single molecule fingerprinting reveals different amplification properties of α-synuclein oligomers and preformed fibrils in seeding assay
This week we discuss Parkinson’s Disease (PD) and single molecule spectroscopy with Dr Derrick Lau, a Postdoc at the University of New South Wales. Single molecular spectroscopy can be used to track the formation and purification of alpha synuclein aggregates, a hallmark of PD, and potentially lead to a tool for early diagnosis of Parkinson’s Disease. We discuss how single molecule spectroscopy is transferable to the early diagnosis of PD and potentially other neurodegenerative diseases. Finally, we discuss preprints, what it’s like to apply for Postdocs in a pandemic as well transitioning from immunology and neuroscience.
These episodes were produced by Emma Wilson and edited by Jonny Coates and John D Howard.