My research focuses on understanding neurodegeneration, specifically investigating mitochondrial quality control and its role in the mechanisms of Parkinson’s Disease. I conducted my PhD in the Whitworth and De Vos Labs at the University of Sheffield, here I investigated the role of phosphatidylinositols in mitophagy and mitochondrial morphology, using Drosophila models. During this time, I expanded my interest to encompass Mitochondria ER-Contact sites (MERCS) and I developed a split fluorescence protein system which can be used to visualise MERCS. I currently work in the Metzakopian lab within the Dementia Research Institute (DRI) at the University of Cambridge, developing an induced pluripotent stem cells (IPSC) differentiation protocol to generate enteric neurones; these cells can be used in high-throughput CRISPR/Cas9 screen to examine novel genes associated with Parkinson’s Disease. I have also continued my work on MERCS, combining CRISPR/Cas9 screening and split florescent proteins-based system to investigate novel genes involved with MERCS modulation.
Beyond this, I am interested in ‘open science’ and Early Career Research (ECR) development. I am a DRI ECR representative and I’m organising mentoring schemes, social activities and ongoing ECR-focused talks. Outside of science, I am a keen runner, training towards a half marathon and also a skilled Jitsuka, looking to achieve my instructor belt in the coming months.
Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality
Tau assemblies enter the cytosol of neurons in a cholesterol sensitive manner
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