
Emma Wilson
My research focuses on understanding neurodegeneration, specifically investigating mitochondrial quality control and its role in the mechanisms of Parkinson’s Disease. I conducted my PhD in the Whitworth and De Vos Labs at the University of Sheffield, here I investigated the role of phosphatidylinositols in mitophagy and mitochondrial morphology, using Drosophila models. During this time, I expanded my interest to encompass Mitochondria ER-Contact sites (MERCS) and I developed a split fluorescence protein system which can be used to visualise MERCS. I currently work in the Metzakopian lab within the Dementia Research Institute (DRI) at the University of Cambridge, developing an induced pluripotent stem cells (IPSC) differentiation protocol to generate enteric neurones; these cells can be used in high-throughput CRISPR/Cas9 screen to examine novel genes associated with Parkinson’s Disease. I have also continued my work on MERCS, combining CRISPR/Cas9 screening and split florescent proteins-based system to investigate novel genes involved with MERCS modulation.
Beyond this, I am interested in ‘open science’ and Early Career Research (ECR) development. I am a DRI ECR representative and I’m organising mentoring schemes, social activities and ongoing ECR-focused talks. Outside of science, I am a keen runner, training towards a half marathon and also a skilled Jitsuka, looking to achieve my instructor belt in the coming months.
Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality
Selected by | Emma Wilson |
1
Tau assemblies enter the cytosol of neurons in a cholesterol sensitive manner
Selected by | Emma Wilson |
1
Citation needed? Wikipedia and the COVID-19 pandemic
Selected by | Emma Wilson, Jonny Coates |
1
Novel insights in the pathophysiology of α-synuclein dysregulation on D2 receptor activity contributing to the vulnerability of dopamine neurons
Selected by | Emma Wilson |