I’m a newly established Group Leader at the Pioneer Campus within the Helmholtz Center in Munich. The research in my lab focuses on understanding how epigenetic mechanisms and 3D genome organization control cell fate decisions during brain development, evolution and disease.
The long-term goals of my research is to identify how chromatin architecture regulates gene expression at the single cell level and how genome evolution has contributed to the massive expansion of the cortex in humans. To accomplish these goals, my lab uses a multidisciplinary approach combining genomics, single-cell technologies and CRISPR-Cas9 strategies to address fundamental questions in epigenetics and developmental neuroscience.
Simultaneous production of diverse neuronal subtypes during early corticogenesis