Jacky graduated in Pharmacology and Cell Biology from University of Strasbourg (France) where he studied astrocytoma cell migration in the laboratory of Ken TAKEDA. He then moved to the laboratory of Ivan Robert NABI in Montreal (University of Montreal, Canada), and later in Vancouver (University of British Columbia, Canada), where he first studied the interaction between the endoplasmic reticulum and mitochondria. He was in parallel interested in glycosylation of membrane proteins, in particular integrins, and described its importance, in concert with Caveolin-1 (Cav1), in fibronectin fibrillogenesis, focal adhesion dynamics and tumor cell migration. He received his Ph.D. degree in 2007 from both University of Montreal and University of Strasbourg. He then moved to the CNIC in Madrid (Spain) in the laboratory of Miguel Angel del Pozo where he led a study on the implication of Cav1 in biomechanical remodeling of the microenvironment and showed its importance in normal tissue architecture but especially during tumor progression. He then joined the team of Julien VERMOT at the IGBMC in Strasbourg (France) to pursue his interests in mechanotransduction phenomenons using zebrafish as a model. In 2012, he won the « SBCF young scientist » prize for his contribution to Cell Biology and launched his team « Tumor Biomechanics » in 2013 where he develops his interest in the role played by biomechanical forces during tumor progression. Since then, he developed a pioneer intravital correlative imaging approach to track cellular behavior at multiple scales. In 2016, he was nominated to section 22 « Cell Biology » of the CNRS national committee (equivalent to NIH study sections).
3D microenvironment stiffness regulates tumor spheroid growth and mechanics via p21 and ROCK
Polyacrylamide Bead Sensors for in vivo Quantification of Cell-Scale Stress in Zebrafish Development
Tissue flow induces cell shape changes during organogenesis
Zebrafish as a model to investigate the effects of exercise in cancer
Cancer exosomes induce tumor neo-neurogenesis potentiating tumor growth