Menu

Close

Cancer exosomes induce tumor neo-neurogenesis potentiating tumor growth

Marianna Madeo, Paul L. Colbert, Daniel W. Vermeer, Christopher T. Lucido, Elisabeth G. Vichaya, Aaron J. Grossberg, Jacob T. Cain, DesiRae Muirhead, Alex P. Rickel, Zhongkui Hong, William C. Spanos, John H. Lee, Robert Dantzer, Paola D. Vermeer

Preprint posted on December 01, 2018 https://doi.org/10.1101/247452

Extracellular vesicles (EVs) loaded with EphrinB1 drive tumor innervation and subsequent tumor growth

Selected by Jacky G. Goetz

Summary

Extracellular vesicles (EVs) loaded with EphrinB1 drive tumor innervation and subsequent tumor growth

This preprint from the group of Paola Vermeer identifies a new role – innervation that fosters growth – for EVs in tumor progression. This interesting and newly identified role adds to a wide list of pro-tumorigenic functions carried out by EVs. Although anti- and pro-tumorigenic functions have been attributed to tumor-released EVs, these new observations identify EVs as a new means used by tumors to exchange information with nerve fibers.

Bigger picture

This study focuses on a concept – neo-neurogenesis during tumor growth – that has been, in comparison to angiogenesis and lymphangiogenesis, only poorly studied so far. While tumors are known to release neurotrophic factors during growth, the authors reasoned that tumors might have additional mechanisms to secrete functional components driving neo-neurogenesis. Although the reason for this is not fully clear, the authors focused here on EphrinB1, which is an axonal guidance molecule. It is well known that innervation of tumors makes them more aggressive. In addition, tumor innervation could play influential roles in the regulation of immune responses and tumor surveillance. Understanding the mechanisms driving neo-neurogenesis is thus of clinical relevance.

Open questions

Does such a mechanism apply to several tumor types ?

Are there other neurotrophic/guidance molecule factors that could be selectively loaded on EVs ?

Why would tumor neo-neurogenesis require EVs, in addition to classical neurotrophic factors ?

How could we inhibit uptake of EVs in tumor-associated ?

Related references

  1. Magnon et al., Autonomic nerve development contributes to prostate cancer progression. Science 341, 1236361 (2013).

 

Posted on: 30th January 2018 , updated on: 23rd February 2018

Read preprint (1 votes)




  • Author's response

    Paola Vermeer shared

    Thanks for your comments on this preprint.

    Have your say

    Your email address will not be published. Required fields are marked *

    This site uses Akismet to reduce spam. Learn how your comment data is processed.

    Sign up to customise the site to your preferences and to receive alerts

    Register here

    Also in the cancer biology category:

    MRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflicts

    Emily Yun-Chia Chang, James P Wells, Shu-Huei Tsai, et al.



    Selected by Katie Weiner

    1

    Applications, Promises, and Pitfalls of Deep Learning for Fluorescence Image Reconstruction

    Chinmay Belthangady , Loic A. Royer



    Selected by Romain F. Laine

    Basal extrusion drives cell invasion and mechanical stripping of E-cadherin

    John Fadul, Gloria M Slattum, Nadja M Redd, et al.



    Selected by William Hill

    Molecularly distinct models of zebrafish Myc-induced B cell leukemia

    Chiara Borga, Clay Foster, Sowmya Iyer, et al.



    Selected by Hannah Brunsdon

    1

    The landscape of antigen-specific T cells in human cancers

    Bo Li, Longchao Liu, Jian Zhang, et al.



    Selected by Rob Hynds

    1

    Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma.

    Andrea Palamidessi, Chiara Malinverno, Emanuela FRITTOLI, et al.



    Selected by Tim Fessenden

    1

    STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pigmentation pathway

    Alexander Swoboda, Robert Soukup, Katharina Kinslechner, et al.



    Selected by Hannah Brunsdon

    Memory sequencing reveals heritable single cell gene expression programs associated with distinct cellular behaviors

    Sydney M Shaffer, Benjamin L Emert, Ann E. Sizemore, et al.



    Selected by Leighton Daigh

    2

    Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling

    Amber N Stratman, Olivia M Farrelly, Constantinos M Mikelis, et al.



    Selected by Coert Margadant

    Profiling the surface proteome identifies actionable biology for TSC1 mutant cells beyond mTORC1 signaling

    Junnian Wei, Kevin K. Leung, Charles Truillet, et al.



    Selected by Rob Hynds

    1

    Precise tuning of gene expression output levels in mammalian cells

    Yale S. Michaels, Mike B Barnkob, Hector Barbosa, et al.



    Selected by Tim Fessenden

    1

    Moving beyond P values: Everyday data analysis with estimation plots

    Joses Ho, Tayfun Tumkaya, Sameer Aryal, et al.



    Selected by Gautam Dey

    1

    JNK-mediated spindle reorientation in stem cells promotes dysplasia in the aging intestine

    Daniel Hu, Heinrich Jasper



    Selected by Maiko Kitaoka

    Mitotic chromosome alignment is required for proper nuclear envelope reassembly

    Cindy L Fonseca, Heidi LH Malaby, Leslie A Sepaniac, et al.



    Selected by Maiko Kitaoka

    SWI/SNF remains localized to chromatin in the presence of SCHLAP1

    Jesse R Raab, Keriayn N Smith, Camarie C Spear, et al.



    Selected by Carmen Adriaens

    1

    Single-cell Map of Diverse Immune Phenotypes Driven by the Tumor Microenvironment

    Elham Azizi, Ambrose J. Carr, George Plitas, et al.



    Selected by Tim Fessenden

    Also in the cell biology category:

    Super-resolution Molecular Map of Basal Foot Reveals Novel Cilium in Airway Multiciliated Cells

    Quynh Nguyen, Zhen Liu, Rashmi Nanjundappa, et al.



    Selected by Robert Mahen

    Single cell RNA-Seq reveals distinct stem cell populations that drive sensory hair cell regeneration in response to loss of Fgf and Notch signaling

    Mark E. Lush, Daniel C. Diaz, Nina Koenecke, et al.

    AND

    Distinct progenitor populations mediate regeneration in the zebrafish lateral line.

    Eric D Thomas, David Raible



    Selected by Rudra Nayan Das

    1

    Actomyosin-II facilitates long-range retrograde transport of large cargoes by controlling axonal radial contractility

    Tong Wang, Wei Li, Sally Martin, et al.



    Selected by Ivana Viktorinová

    Atlas of Subcellular RNA Localization Revealed by APEX-seq

    Furqan M Fazal, Shuo Han, Pornchai Kaewsapsak, et al.

    AND

    Proximity RNA labeling by APEX-Seq Reveals the Organization of Translation Initiation Complexes and Repressive RNA Granules

    Alejandro Padron, Shintaro Iwasaki, Nicholas Ingolia



    Selected by Christian Bates

    Applications, Promises, and Pitfalls of Deep Learning for Fluorescence Image Reconstruction

    Chinmay Belthangady , Loic A. Royer



    Selected by Romain F. Laine

    Stable knockout and complementation of receptor expression using in vitro cell line derived reticulocytes for dissection of host malaria invasion requirements

    Timothy J Satchwell, Katherine E Wright, Katy L Haydn-Smith, et al.



    Selected by Alyson Smith

    Maintenance of spatial gene expression by Polycomb-mediated repression after formation of a vertebrate body plan

    Julien Rougot, Naomi D Chrispijn, Marco Aben, et al.



    Selected by Yen-Chung Chen

    1

    Activation of intracellular transport by relieving KIF1C autoinhibition

    Nida Siddiqui, Alice Bachmann, Alexander J Zwetsloot, et al.



    Selected by Ben Craske, Thibault Legal and Toni McHugh

    1

    A non-canonical arm of UPRER mediates longevity through ER remodeling and lipophagy.

    Joseph R Daniele, Ryo Higuchi-Sanabria, Vidhya Ramachandran, et al.



    Selected by Sandra Franco Iborra

    1

    Basal extrusion drives cell invasion and mechanical stripping of E-cadherin

    John Fadul, Gloria M Slattum, Nadja M Redd, et al.



    Selected by William Hill

    Ribosomal DNA and the rDNA-binding protein Indra mediate non-random sister chromatid segregation in Drosophila male germline stem cells

    George Watase, Yukiko Yamashita



    Selected by Maiko Kitaoka

    An F-actin shell ruptures the nuclear envelope by sorting pore-dense and pore-free membranes in meiosis of starfish oocytes

    Natalia Wesolowska, Pedro Machado, Celina Geiss, et al.



    Selected by Maiko Kitaoka

    1

    Multi-color single molecule imaging uncovers extensive heterogeneity in mRNA decoding

    Sanne Boersma, Deepak Khuperkar, Bram M.P. Verhagen, et al.



    Selected by Lorenzo Lafranchi

    Multi-color single molecule imaging uncovers extensive heterogeneity in mRNA decoding

    Sanne Boersma, Deepak Khuperkar, Bram M.P. Verhagen, et al.

    AND

    Live-cell single RNA imaging reveals bursts of translational frameshifting

    Kenneth R Lyon Jr, Luis U Aguilera, Tatsuya Morisaki, et al.



    Selected by Nicola Stevenson

    A non-canonical arm of UPRER mediates longevity through ER remodeling and lipophagy.

    Joseph R Daniele, Ryo Higuchi-Sanabria, Vidhya Ramachandran, et al.



    Selected by Sandra Malmgren Hill

    Microtubules Gate Tau Condensation to Spatially Regulate Microtubule Functions

    Ruensern Tan, Aileen J. Lam, Tracy Tan, et al.

    AND

    Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes

    Valerie Siahaan, Jochen Krattenmacher, Amayra Hernandez-Vega, et al.



    Selected by Satish Bodakuntla

    2

    Close