Cancer exosomes induce tumor neo-neurogenesis potentiating tumor growth

Marianna Madeo, Paul L. Colbert, Daniel W. Vermeer, Christopher T. Lucido, Elisabeth G. Vichaya, Aaron J. Grossberg, Jacob T. Cain, DesiRae Muirhead, Alex P. Rickel, Zhongkui Hong, William C. Spanos, John H. Lee, Robert Dantzer, Paola D. Vermeer

Preprint posted on December 01, 2018

Extracellular vesicles (EVs) loaded with EphrinB1 drive tumor innervation and subsequent tumor growth

Selected by Jacky G. Goetz


Extracellular vesicles (EVs) loaded with EphrinB1 drive tumor innervation and subsequent tumor growth

This preprint from the group of Paola Vermeer identifies a new role – innervation that fosters growth – for EVs in tumor progression. This interesting and newly identified role adds to a wide list of pro-tumorigenic functions carried out by EVs. Although anti- and pro-tumorigenic functions have been attributed to tumor-released EVs, these new observations identify EVs as a new means used by tumors to exchange information with nerve fibers.

Bigger picture

This study focuses on a concept – neo-neurogenesis during tumor growth – that has been, in comparison to angiogenesis and lymphangiogenesis, only poorly studied so far. While tumors are known to release neurotrophic factors during growth, the authors reasoned that tumors might have additional mechanisms to secrete functional components driving neo-neurogenesis. Although the reason for this is not fully clear, the authors focused here on EphrinB1, which is an axonal guidance molecule. It is well known that innervation of tumors makes them more aggressive. In addition, tumor innervation could play influential roles in the regulation of immune responses and tumor surveillance. Understanding the mechanisms driving neo-neurogenesis is thus of clinical relevance.

Open questions

Does such a mechanism apply to several tumor types ?

Are there other neurotrophic/guidance molecule factors that could be selectively loaded on EVs ?

Why would tumor neo-neurogenesis require EVs, in addition to classical neurotrophic factors ?

How could we inhibit uptake of EVs in tumor-associated ?

Related references

  1. Magnon et al., Autonomic nerve development contributes to prostate cancer progression. Science 341, 1236361 (2013).


Read preprint (1 votes)

  • Author's response

    Paola Vermeer shared

    Thanks for your comments on this preprint.

    Have your say

    Your email address will not be published. Required fields are marked *

    Sign up to customise the site to your preferences and to receive alerts

    Register here

    Also in the cell biology category:

    Long-term live imaging of the Drosophila adult midgut reveals real-time dynamics of cell division, differentiation, and loss

    Judy Martin, Erin Nicole Sanders, Paola Moreno-Roman, et al.

    Selected by Natalie Dye

    A role for RNA and DNA:RNA hybrids in the modulation of DNA repair by homologous recombination

    Giuseppina D'Alessandro, Marek Adamowicz, Donna Whelan, et al.

    Selected by Carmen Adriaens

    Nuclear envelope assembly defects link mitotic errors to chromothripsis

    Shiwei Liu, Mijung Kwon, Mark Mannino, et al.

    Selected by Gautam Dey

    A 3D model of human skeletal muscle innervated with stem cell-derived motor neurons enables epsilon-subunit targeted myasthenic syndrome studies

    Mohsen Afshar Bakooshli, Ethan S Lippmann, Ben Mulcahy, et al.

    Selected by Chris Demers

    Tunable molecular tension sensors reveal extension-based control of vinculin loading

    Andrew S LaCroix, Andrew D Lynch, Matthew E Berginski, et al.

    Selected by Amanda Haage


    Persistent cell motility requires transcriptional feedback of cytoskeletal – focal adhesion equilibrium by YAP/TAZ

    Devon E Mason, James H Dawahare, Trung Dung Nguyen, et al.

    Selected by Carla Mulas


    Dynamin-2 facilitates Atg9 recycling from nascent autophagosomes

    Alejandro Martorell Riera, Cinta Iriondo Martinez, Samuel Itskanov, et al.

    Selected by Justin Joachim

    Focal adhesion kinase regulates early steps of myofibrillogenesis in cardiomyocytes

    Nilay Taneja, Abigail C Neininger, Matthew R Bersi, et al.

    Selected by Vassilis Papalazarou

    Content-Aware Image Restoration: Pushing the Limits of Fluorescence Microscopy

    Martin Weigert, Uwe Schmidt, Tobias Boothe, et al.

    Selected by Uri Manor

    Reticular adhesions: A new class of adhesion complex that mediates cell-matrix attachment during mitosis

    John G Lock, Matthew C Jones, Janet A Askari, et al.

    Selected by Guillaume Jacquemet

    In vivo topology converts competition for cell-matrix adhesion into directional migration

    Fernanda Bajanca, Nadege Gouignard, Charlotte Colle, et al.

    Selected by Helen Zenner

    The expa1-1 mutant reveals a new biophysical lateral root organogenesis checkpoint

    Priya Ramakrishna, Graham A. Rance, Lam D. Vu, et al.

    Selected by Annika Weimer


    F-actin patches nucleated on chromosomes coordinate capture by microtubules in oocyte meiosis

    Mariia Burdyniuk, Andrea Callegari, Masashi Mori, et al.

    Selected by Binyam Mogessie

    Heterochromatin drives organization of conventional and inverted nuclei

    Martin Falk, Yana Feodorova, Natasha Naumova, et al.

    Selected by Boyan Bonev

    Comprehensive characterization of transcript diversity at the human NODAL locus

    Scott D Findlay, Lynne-Marie Postovit

    Selected by Christian Ramos

    Cell-matrix adhesion controls Golgi organization and function by regulating Arf1 activation in anchorage-dependent cells.

    Vibha Singh, Chaitanya Erady, Nagaraj Balasubramanian

    Selected by Nicola Stevenson

    We want to make our website, and the services we provide, useful and reliable. This sometimes involves placing small amounts of information called cookies on the device you used to access the internet. If you continue to use this website we will assume you are happy to accept our cookies.