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MitoList
This list of preprints is focused on work expanding our knowledge on mitochondria in any organism, tissue or cell type, from the normal biology to the pathology.
List by Sandra Franco Iborra
Preprints:
Mitochondrial fusion in reactive astrocytes coordinates local metabolic domains to promote vascular repair
https://www.biorxiv.org/content/10.1101/657999v1?rss=1
In the context of injured central nervous system, dysfunction in the blood-brain barrier (BBB) is starting to gain some attention. BBB is formed by the brain endothelial cells, pericytes and astrocytes’ end-feet processes. It has been already shown that astrocytes, upon injury, can adapt their metabolic state modifying the architecture of the mitochondrial network. In this preprint, authors provide evidence of the importance of this mitochondrial network remodeling in astrocytes’ processes to ellicit vascular repair in the injured area.
Mitochondria form cholesterol tethered contact sites with the Nucleus to regulate retrograde response
https://www.biorxiv.org/content/10.1101/445411v2
Contact sites between mitochondria and many organelles are being unraveled. Those contact sites are believed to play an important role in lipid and ion exchange, membrane dynamics and signalling. This preprint highlights the presence of a specific tethering between mitochondria and the nucleus based in cholesterol.
Profound functional and molecular diversity of mitochondria revealed by cell type-specific profiling in vivo
https://www.biorxiv.org/content/10.1101/403774v1
We are all aware about the different mitochondrial morphologies that can take place in different cell types. But what about molecular differences? In this preprint Fecher et al., developed a method to isolate cell type-specific mitochondria from the MitoTag mouse and analyzed the proteome landscape of mitochondria from different tissues.
Mitochondria-derived vesicles deliver antimicrobial payload to control phagosomal bacteria
https://www.biorxiv.org/content/10.1101/277004v1
Mitochondria-derived vesicles (MDV) have been reported to transport mitochondrial components to other intracellular compartments. MDV are described as a quality control system for mitochondria. However, in this preprint, Abuaita et al. describe a new function for MDVs in enhancing macrophage antimicrobial funcion.
Presynaptic boutons that contain mitochondria are more stable
https://www.biorxiv.org/content/10.1101/580530v1
Mitochondria localization in presynaptic structures is positively correlated with synaptic efficacy. Here, authors focus on the study of mitochondrial spatial distribution to presynaptic boutons and how this related to presynaptic structure plasticity. Interestingly, studies are carried in mice using in vivo two-photon imaging.
Mitochondria-Associated Membranes (MAMs) are involved in Bax mitochondrial localization and cytochrome c release
https://www.biorxiv.org/content/10.1101/443606v1
Mitochondria-Associated Membranes or MAM are specific microdomains in ER membrane in close contact to the outer mitochondrial membrane. MAMs are sites of ER and mitochondria communication via lipid synthesis or calcium transfer. In this preprint, authors study the role of MAM stability in Bax localization and implicate this highly dynamic compartment in the regulation of apoptosis.
Categories: biochemistry , cell biology , molecular biology
Posted on: 20th May 2019 , updated on: 6th June 2019
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