Preprint highlights, selected by the biological community

MitoList

This list of preprints is focused on work expanding our knowledge on mitochondria in any organism, tissue or cell type, from the normal biology to the pathology.

List by Sandra Franco Iborra

Preprints:

Mitochondrial fusion in reactive astrocytes coordinates local metabolic domains to promote vascular repair

Jana Göbel, Patric Pelzer, Esther Engelhardt, Vignesh Sakthivelu, Hannah M. Jahn, Milica Jevtic, Kat Folz-Donahue, Christian Kukat, Astrid Schauss, Christian K. Frese, Alexander Ghanem, Karl-Klaus Conzelmann, Elisa Motori, Matteo Bergami

https://www.biorxiv.org/content/10.1101/657999v1?rss=1

In the context of injured central nervous system, dysfunction in the blood-brain barrier (BBB) is starting to gain some attention. BBB is formed by the brain endothelial cells, pericytes and astrocytes’ end-feet processes. It has been already shown that astrocytes, upon injury, can adapt their metabolic state modifying the architecture of the mitochondrial network. In this preprint, authors provide evidence of the importance of this mitochondrial network remodeling in astrocytes’ processes to ellicit vascular repair in the injured area.

Mitochondria form cholesterol tethered contact sites with the Nucleus to regulate retrograde response

Radha Desai, Daniel A East, Liana Hardy, James Crosby, Manuel Rigon, Danilo Faccenda, María Soledad Alvarez, Arti Singh, Marta Mainenti, Laura Kuhlman Hussey, Robert Bentham, Gyorgy Szabadkai, Valentina Zappulli, Gurtej Dhoot, Lisa E Romano, Xia Dong, Anne Hamechar-Brady, J Paul Chapple, Roland A. Fleck, Gema Vizcay-Barrena, Kenneth Smith, Michelangelo Campanella

https://www.biorxiv.org/content/10.1101/445411v2

Contact sites between mitochondria and many organelles are being unraveled. Those contact sites are believed to play an important role in lipid and ion exchange, membrane dynamics and signalling. This preprint highlights the presence of a specific tethering between mitochondria and the nucleus based in cholesterol.

Profound functional and molecular diversity of mitochondria revealed by cell type-specific profiling in vivo

Caroline Fecher, Laura Trovò, Stephan A. Müller, Nicolas Snaidero, Jennifer Wettmarshausen, Sylvia Heink, Oskar Ortiz, Ingrid Wagner, Ralf Kühn, Jana Hartmann, Rosa Maria Karl, Arthur Konnerth, Thomas Korn, Wolfgang Wurst, Doron Merkler, Stefan F. Lichtenthaler, Fabiana Perocchi, Thomas Misgeld

https://www.biorxiv.org/content/10.1101/403774v1

We are all aware about the different mitochondrial morphologies that can take place in different cell types. But what about molecular differences? In this preprint Fecher et al., developed a method to isolate cell type-specific mitochondria from the MitoTag mouse and analyzed the proteome landscape of mitochondria from different tissues.

Mitochondria-derived vesicles deliver antimicrobial payload to control phagosomal bacteria

Basel H. Abuaita, Tracey L. Schultz, Mary X. O’Riordan

https://www.biorxiv.org/content/10.1101/277004v1

Mitochondria-derived vesicles (MDV) have been reported to transport mitochondrial components to other intracellular compartments. MDV are described as a quality control system for mitochondria. However, in this preprint, Abuaita et al. describe a new function for MDVs in enhancing macrophage antimicrobial funcion.

Presynaptic boutons that contain mitochondria are more stable

Robert M. Lees, James D. Johnson, Michael C. Ashby

https://www.biorxiv.org/content/10.1101/580530v1

Mitochondria localization in presynaptic structures is positively correlated with synaptic efficacy. Here, authors focus on the study of mitochondrial spatial distribution to presynaptic boutons and how this related to presynaptic structure plasticity. Interestingly, studies are carried in mice using in vivo two-photon imaging.

Mitochondria-Associated Membranes (MAMs) are involved in Bax mitochondrial localization and cytochrome c release

Alexandre Légiot, Claire Céré, Thibaud Dupoiron, Mohamed Kaabouni, Stéphen Manon

https://www.biorxiv.org/content/10.1101/443606v1

Mitochondria-Associated Membranes or MAM are specific microdomains in ER membrane in close contact to the outer mitochondrial membrane. MAMs are sites of ER and mitochondria communication via lipid synthesis or calcium transfer. In this preprint, authors study the role of MAM stability in Bax localization and implicate this highly dynamic compartment in the regulation of apoptosis.

Categories: biochemistry , cell biology , molecular biology

Posted on: 20th May 2019 , updated on: 6th June 2019

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Sandra Franco Iborra