Menu

Close
Close

preLights is supported by…

Related posts

Related preLists

Biophysical Society Annual Meeting 2019

Few of the preprints that were discussed in the recent BPS annual meeting at Baltimore, USA

List by Joseph Jose Thottacherry

Preprints:

Myosin-II mediated traction forces evoke localized Piezo1 Ca2+ flickers

Kyle L. Ellefsen, Alice Chang, Jamison L. Nourse, Jesse R. Holt, Janahan Arulmoli, Armen Mekhdjian, Hamid Abuwarda, Francesco Tombola, Lisa A. Flanagan, Alexander R. Dunn, Ian Parker, Medha M. Pathak

https://www.biorxiv.org/content/10.1101/294611v2

Piezo 1 channels are mobile at the plasma membrane and releases calcium in response to local traction forces.

Tumor suppressor DAPK1 catalyzes Adhesion Assembly on Rigid but Anoikis on Soft Matrices

Ruifang Qin, Haguy Wolfenson, Mayur Saxena, Michael P. Sheetz

https://www.biorxiv.org/content/10.1101/320739v2.full

DAPK1 is important for adhesion assembly on rigid surfaces and apoptosis on soft surfaces (anoikis) through its binding to rigidity-sensing modules.

Ligand Geometry Controls Adhesion formation via Integrin Clustering

Rishita Changede, Haogang Cai, Shalom Wind, Michael P. Sheetz

https://www.biorxiv.org/content/10.1101/435826v1

This study uses nanopatterning to mimic ECM fibers to study cell adhesion and shows that unliganded integrins can co-cluster to bridge between thin matrix fibers and thus form stable integrin adhesions on dense fibrous networks.

Synaptic vesicles undock and then transiently dock after an action potential

Grant F Kusick, Morven Chin, Kristina Lippmann, Kadidia P Adula, M Wayne Davis, Erik M Jorgensen, Shigeki Watanabe

https://www.biorxiv.org/content/10.1101/509216v1

This study utilizes high pressure freezing and electron microscopy following an action potential in neurons to capture rapid synaptic vesicle fusions and unexpected docking dynamics.

Cell cycle repression and DNA repair defects follow constricted migration

Charlotte R. Pfeifer, Yuntao Xia, Kuangzheng Zhu, Dazhen Liu, Jerome Irianto, Shane Harding, Roger A. Greenberg, Dennis E. Discher

https://www.biorxiv.org/content/10.1101/240838v1

Cell migration into tissue or narrow capillaries often elongates the nucleus and sometimes damages it and this study shows that it impacts cell cycle as well as causes DNA damage.

Rescue of DNA damage in cells after constricted migration reveals bimodal mechano-regulation of cell cycle

Yuntao Xia, Charlotte R. Pfeifer, Kuangzheng Zhu, Jerome Irianto, Dazhen Liu, Kalia Pannell, Emily J. Chen, Lawrence J. Dooling, Roger A. Greenberg, Dennis E. Discher

https://www.biorxiv.org/content/10.1101/508200v1

Constricted cell migration through tissues is studied using custom-etched pores and shows increased genomic variation during subsequent proliferation.

Categories: biophysics , cancer biology , cell biology

Tags: imaging , mechanobiology

Posted on: 18th May 2019 , updated on: 8th November 2019

(No Ratings Yet)




    • Have your say

    Your email address will not be published. Required fields are marked *

    This site uses Akismet to reduce spam. Learn how your comment data is processed.

    Sign up to customise the site to your preferences and to receive alerts

    Register here

    Also in the biophysics category:

    Biophysical Society Meeting 2020

    Some preprints presented at the Biophysical Society Meeting 2020 in San Diego, USA.

     



    List by Tessa Sinnige

    ASCB EMBO Annual Meeting 2019

    A collection of preprints presented at the 2019 ASCB EMBO Meeting in Washington, DC (December 7-11)

     



    List by Madhuja Samaddar, Ramona Jühlen, Amanda Haage, Laura McCormick, Maiko Kitaoka

    EMBL Seeing is Believing – Imaging the Molecular Processes of Life

    Preprints discussed at the 2019 edition of Seeing is Believing, at EMBL Heidelberg from the 9th-12th October 2019

     



    List by Gautam Dey

    Biomolecular NMR

    Preprints related to the application and development of biomolecular NMR spectroscopy

     



    List by Reid Alderson

    Also in the cancer biology category:

    ASCB EMBO Annual Meeting 2019

    A collection of preprints presented at the 2019 ASCB EMBO Meeting in Washington, DC (December 7-11)

     



    List by Madhuja Samaddar, Ramona Jühlen, Amanda Haage, Laura McCormick, Maiko Kitaoka

    Lung Disease and Regeneration

    This preprint list compiles highlights from the field of lung biology.

     



    List by Rob Hynds

    Anticancer agents: Discovery and clinical use

    Preprints that describe the discovery of anticancer agents and their clinical use. Includes both small molecules and macromolecules like biologics.

     



    List by Zhang-He Goh

    Biophysical Society Annual Meeting 2019

    Few of the preprints that were discussed in the recent BPS annual meeting at Baltimore, USA

     



    List by Joseph Jose Thottacherry

    Also in the cell biology category:

    3D Gastruloids

    A curated list of preprints related to Gastruloids (in vitro models of early development obtained by 3D aggregation of embryonic cells)

     



    List by Paul Gerald L. Sanchez and Stefano Vianello

    ECFG15 – Fungal biology

    Preprints presented at 15th European Conference on Fungal Genetics 17-20 February 2020 Rome

     



    List by Hiral Shah

    ASCB EMBO Annual Meeting 2019

    A collection of preprints presented at the 2019 ASCB EMBO Meeting in Washington, DC (December 7-11)

     



    List by Madhuja Samaddar, Ramona Jühlen, Amanda Haage, Laura McCormick, Maiko Kitaoka

    EMBL Seeing is Believing – Imaging the Molecular Processes of Life

    Preprints discussed at the 2019 edition of Seeing is Believing, at EMBL Heidelberg from the 9th-12th October 2019

     



    List by Gautam Dey

    Autophagy

    Preprints on autophagy and lysosomal degradation and its role in neurodegeneration and disease. Includes molecular mechanisms, upstream signalling and regulation as well as studies on pharmaceutical interventions to upregulate the process.

     



    List by Sandra Malmgren Hill

    Lung Disease and Regeneration

    This preprint list compiles highlights from the field of lung biology.

     



    List by Rob Hynds

    Cellular metabolism

    A curated list of preprints related to cellular metabolism at Biorxiv by Pablo Ranea Robles from the Prelights community. Special interest on lipid metabolism, peroxisomes and mitochondria.

     



    List by Pablo Ranea Robles

    BSCB/BSDB Annual Meeting 2019

    Preprints presented at the BSCB/BSDB Annual Meeting 2019

     



    List by Gautam Dey

    MitoList

    This list of preprints is focused on work expanding our knowledge on mitochondria in any organism, tissue or cell type, from the normal biology to the pathology.

     



    List by Sandra Franco Iborra

    ASCB/EMBO Annual Meeting 2018

    This list relates to preprints that were discussed at the recent ASCB conference.

     



    List by Gautam Dey, Amanda Haage

    Also in the biophysics category:

    The single flagellum of Leishmania has a fixed polarisation of its asymmetric beat

    Ziyin Wang, Tom Beneke, Eva Gluenz, et al.



    Selected by Mariana De Niz

    1

    CryoEM structure of the Vibrio cholerae Type IV competence pilus secretin PilQ

    Sara J. Weaver, Matthew H. Sazinsky, Triana N. Dalia, et al.



    Selected by NYUPeerReview

    Tissue size controls patterns of cell proliferation and migration in freely-expanding epithelia

    Matthew A. Heinrich, Julienne M. LaChance, Tom J. Zajdel, et al.



    Selected by Mariana De Niz

    1

    Also in the cancer biology category:

    Constricted migration contributes to persistent 3D genome structure changes associated with an invasive phenotype in melanoma cells

    Rosela Golloshi, Rebeca San Martin, Priyojit Das, et al.



    Selected by Mariana De Niz

    1

    Drug mechanism-of-action discovery through the integration of pharmacological and CRISPR screens

    Emanuel Gonçalves, Aldo Segura-Cabrera, Clare Pacini, et al.



    Selected by Georgina Sava

    1

    CoolMPS™: Advanced massively parallel sequencing using antibodies specific to each natural nucleobase

    Snezana Drmanac, Matthew Callow, Linsu Chen, et al.



    Selected by Kerryn Elliott

    Also in the cell biology category:

    ActuAtor, a molecular tool for generating force in living cells: Controlled deformation of intracellular structures

    Hideki Nakamura, Elmer Rho, Daqi Deng, et al.



    Selected by Helena Pinheiro

    The single flagellum of Leishmania has a fixed polarisation of its asymmetric beat

    Ziyin Wang, Tom Beneke, Eva Gluenz, et al.



    Selected by Mariana De Niz

    1

    Circumvention of common labeling artifacts using secondary nanobodies

    Shama Sograte-Idrissi, Thomas Schlichthaerle, Carlos J. Duque-Afonso, et al.



    Selected by Mariana De Niz
    Close