Menu

Close

Lung Disease and Regeneration

This preprint list compiles highlights from the field of lung biology.

List by Rob Hynds

Preprints:

Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium

Katherine C. Goldfarbmuren, Nathan D. Jackson, Satria P. Sajuthi, Nathan Dyjack, Katie S. Li, Cydney L. Rios, Elizabeth G. Plender, Michael T. Montgomery, Jamie L. Everman, Eszter K. Vladar, Max A. Seibold

https://www.biorxiv.org/content/10.1101/612747v1

A single cell transcriptomics study comparing human airway epithelium from smokers and non-smoking controls.

STK11 is required for the normal program of ciliated cell differentiation in airways

Qiqi Chu, Changfu Yao, Xiangbing Qi, Barry Raymond Stripp, Nan Tang

https://www.biorxiv.org/content/10.1101/652107v1

STK11 is a tumor supressor gene mutated in some lung cancers. Mutations are associated with resistance to anti-PD-1/PD-L1 immune checkpoint blockade and is a key mediator of tumour lineage in mouse lung cancer models. This preprint implicates STK11 signalling in multiciliogenesis in normal airways.

A cellular census of healthy lung and asthmatic airway wall identifies novel cell states in health and disease

Felipe A Vieira Braga, Gozde Kar, Marijn Berg, Orestes A Carpaij, Krzysztof Polanski, Lukas M Simon, Sharon Brouwer, Tomas Gomes, Laura Hesse, Jian Jiang, Eirini S Fasouli, Mirjana Efremova, Roser Vento-Tormo, Karen Affleck, Subarna Palit, Paulina Strzelecka, Helen V Firth, Krishnaa TA Mahbubani, Ana Cvejic, Kerstin B Meyer, Kourosh Saeb-Parsy, Marjan Luinge, Corry-Anke Brandsma, Wim Timens, Ilias Angelidis, Maximilian Strunz, Gerard H Koppelman, Antoon J van Oosterhout, Herbert B Schiller, Fabian J Theis, Maarten van den Berge, Martijn C Nawijn, Sarah A Teichmann

https://www.biorxiv.org/content/10.1101/527408v1

A single cell transcriptomics study of normal and asthmatic human airways. The preprint reveals spatial differences in airway epithelial cells and a disease associated subpopulation of tissue-resident T cells. Now published at Nature Medicine.

A smooth muscle-like niche facilitates lung epithelial regeneration

Alena Moiseenko, Ana Ivonne Vazquez-Armendariz, Xuran Chu, Stefan Guenther, Kevin Lebrigand, Vahid Kheirollahi, Susanne Herold, Thomas Braun, Bernard Mari, Stijn De Langhe, Chengshui Chen, Xiaokun Li, Werner Seeger, Jin-San Zhang, Saverio Bellusci, Elie El Agha

https://www.biorxiv.org/content/10.1101/565085v1

Mesenchymal heterogeneity in the lung is poorly understood. This preprint delineates distinct smooth muscle populations with roles in airway regeneration.

Single-cell RNA sequencing reveals novel cell differentiation dynamics during human airway epithelium regeneration

Sandra Ruiz Garcia, Marie Deprez, Kevin Lebrigand, Agnès Paquet, Amélie Cavard, Marie-Jeanne Arguel, Virginie Magnone, Ignacio Caballero, Sylvie Leroy, Charles-Hugo Marquette, Brice Marcet, Pascal Barbry, Laure-Emmanuelle Zaragosi

https://www.biorxiv.org/content/10.1101/451807v1

This preprint includes single cell RNAseq analysis of airway epithelial cell differentiation in the air-liquid interface culture system. preLight here.

Human Lung Epithelial Cells Divide >200 Population Doublings without Engaging a Telomere Maintenance Mechanism

Jennifer R. Peters-Hall, Jaewon Min, Enzo Tedone, Sei Sho, Silvia Siteni, Ilgen Mender, Jerry W. Shay

https://www.biorxiv.org/content/10.1101/474270v2

This preprint demonstrates extensive expansion of human airway basal stem cells in culture and assesses the mechanisms engaged during in vitro epithelial cell senescence.

Human lung organoids develop into adult airway-like structures directed by physico-chemical biomaterial properties

Briana R Dye, Richard L Youngblood, Robert S Oakes, Tadas Kasputis, Daniel W Clough, Melinda S Nagy, Jason R Spence, Lonnie D Shea

https://www.biorxiv.org/content/10.1101/564252v1

An interesting study about the interactions between iPSC-derived lung organoids and biomaterials.

Restored alveolar epithelial differentiation and reversed human lung fibrosis upon Notch inhibition

RM Wasnick, M Korfei, K Piskulak, I Henneke, J Wilhelm, P Mahavadi, D von der Beck, M Koch, I Shalashova, O Klymenko, L Fink, H Witt, H Hackstein, E El Agha, S Bellusci, W Klepetko, M Königshoff, O Eickelberg, T Braun, W Seeger, C Ruppert, A Guenther

https://www.biorxiv.org/content/10.1101/580498v2

Investigation of Notch as a target in pulmonary fibrosis, including in human precision-cut lung slices.

Basal stem cell fate specification is mediated by SMAD signaling in the developing human lung

Alyssa J. Miller, Qianhui Yu, Michael Czerwinski, Yu-Hwai Tsai, Renee F. Conway, Angeline Wu, Emily M. Holloway, Taylor Walker, Ian A. Glass, Barbara Treutlein, J. Gray Camp, Jason R. Spence

https://www.biorxiv.org/content/10.1101/461103v1

Insight into the early developmental specification of airway basal stem/progenitor cells.

An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics

Ilias Angelidis, Lukas M. Simon, Isis E. Fernandez, Maximilian Strunz, Christoph H. Mayr, Flavia R. Greiffo, George Tsitsiridis, Elisabeth Graf, Tim-Matthias Strom, Oliver Eickelberg, Matthias Mann, Fabian J. Theis, Herbert B. Schiller

https://www.biorxiv.org/content/10.1101/351353v1

Single cell RNA sequencing study to assess the effects of ageing in a cell-type resolved manner in mice. preLight here and now published at Nature Communications.

Single-Cell Transcriptomic Analysis of Human Lung Reveals Complex Multicellular Changes During Pulmonary Fibrosis

Paul A. Reyfman, James M. Walter, Nikita Joshi, Kishore R. Anekalla, Alexandra C. McQuattie-Pimentel, Stephen Chiu, Ramiro Fernandez, Mahzad Akbarpour, Ching-I Chen, Ziyou Ren, Rohan Verma, Hiam Abdala-Valencia, Kiwon Nam, Monica Chi, SeungHye Han, Francisco J. Gonzalez-Gonzalez, Saul Soberanes, Satoshi Watanabe, Kinola J.N. Williams, Annette S Flozak, Trevor T. Nicholson, Vince K. Morgan, Cara L. Hrusch, Robert D. Guzy, Catherine A. Bonham, Anne I. Sperling, Remzi Bag, Robert B. Hamanaka, Gökhan M. Mutlu, Anjana V. Yeldandi, Stacy A. Marshall, Ali Shilatifard, Luis A.N. Amaral, Harris Perlman, Jacob I. Sznajder, Deborah R. Winter, Monique Hinchcliff, A. Christine Argento, Colin T. Gillespie, Jane D’Amico Dematte, Manu Jain, Benjamin D. Singer, Karen M. Ridge, Cara J. Gottardi, Anna P. Lam, Ankit Bharat, Sangeeta M. Bhorade, G.R. Scott Budinger, Alexander V. Misharin

https://www.biorxiv.org/content/10.1101/296608v1

Single cell transcriptomic analysis of human pulmonary fibrosis. Now published at the American Journal of Respiratory and Critical Care Medicine.

Categories: bioengineering , cancer biology , cell biology , developmental biology , molecular biology

Tags: airway , lung cancer , regenerative medicine , respiratory , stem cells

Posted on: 27th May 2019 , updated on: 19th June 2019

(No Ratings Yet)




  • Have your say

    Your email address will not be published. Required fields are marked *

    This site uses Akismet to reduce spam. Learn how your comment data is processed.

    Sign up to customise the site to your preferences and to receive alerts

    Register here

    Also in the cell biology category:

    FENS 2020

    A collection of preprints presented during the virtual meeting of the Federation of European Neuroscience Societies (FENS) in 2020

     



    List by Ana Dorrego-Rivas

    Planar Cell Polarity – PCP

    This preList contains preprints about the latest findings on Planar Cell Polarity (PCP) in various model organisms at the molecular, cellular and tissue levels.

     



    List by Ana Dorrego-Rivas

    BioMalPar XVI: Biology and Pathology of the Malaria Parasite

    [under construction] Preprints presented at the (fully virtual) EMBL BioMalPar XVI, 17-18 May 2020 #emblmalaria

     



    List by Gautam Dey, Samantha Seah

    1

    Cell Polarity

    Recent research from the field of cell polarity is summarized in this list of preprints. It comprises of studies focusing on various forms of cell polarity ranging from epithelial polarity, planar cell polarity to front-to-rear polarity.

     



    List by Yamini Ravichandran

    TAGC 2020

    Preprints recently presented at the virtual Allied Genetics Conference, April 22-26, 2020. #TAGC20

     



    List by Maiko Kitaoka, Madhuja Samaddar, Miguel V. Almeida, Sejal Davla, Jennifer Ann Black, Gautam Dey

    3D Gastruloids

    A curated list of preprints related to Gastruloids (in vitro models of early development obtained by 3D aggregation of embryonic cells)

     



    List by Paul Gerald L. Sanchez and Stefano Vianello

    ECFG15 – Fungal biology

    Preprints presented at 15th European Conference on Fungal Genetics 17-20 February 2020 Rome

     



    List by Hiral Shah

    ASCB EMBO Annual Meeting 2019

    A collection of preprints presented at the 2019 ASCB EMBO Meeting in Washington, DC (December 7-11)

     



    List by Madhuja Samaddar, Ramona Jühlen, Amanda Haage, Laura McCormick, Maiko Kitaoka

    EMBL Seeing is Believing – Imaging the Molecular Processes of Life

    Preprints discussed at the 2019 edition of Seeing is Believing, at EMBL Heidelberg from the 9th-12th October 2019

     



    List by Gautam Dey

    Autophagy

    Preprints on autophagy and lysosomal degradation and its role in neurodegeneration and disease. Includes molecular mechanisms, upstream signalling and regulation as well as studies on pharmaceutical interventions to upregulate the process.

     



    List by Sandra Malmgren Hill

    Lung Disease and Regeneration

    This preprint list compiles highlights from the field of lung biology.

     



    List by Rob Hynds

    Cellular metabolism

    A curated list of preprints related to cellular metabolism at Biorxiv by Pablo Ranea Robles from the Prelights community. Special interest on lipid metabolism, peroxisomes and mitochondria.

     



    List by Pablo Ranea Robles

    BSCB/BSDB Annual Meeting 2019

    Preprints presented at the BSCB/BSDB Annual Meeting 2019

     



    List by Gautam Dey

    MitoList

    This list of preprints is focused on work expanding our knowledge on mitochondria in any organism, tissue or cell type, from the normal biology to the pathology.

     



    List by Sandra Franco Iborra

    ASCB/EMBO Annual Meeting 2018

    This list relates to preprints that were discussed at the recent ASCB conference.

     



    List by Gautam Dey, Amanda Haage

    Also in the developmental biology category:

    Society for Developmental Biology 79th Annual Meeting

    Preprints at SDB 2020

     



    List by Irepan Salvador-Martinez, Martin Estermann

    FENS 2020

    A collection of preprints presented during the virtual meeting of the Federation of European Neuroscience Societies (FENS) in 2020

     



    List by Ana Dorrego-Rivas

    Planar Cell Polarity – PCP

    This preList contains preprints about the latest findings on Planar Cell Polarity (PCP) in various model organisms at the molecular, cellular and tissue levels.

     



    List by Ana Dorrego-Rivas

    Cell Polarity

    Recent research from the field of cell polarity is summarized in this list of preprints. It comprises of studies focusing on various forms of cell polarity ranging from epithelial polarity, planar cell polarity to front-to-rear polarity.

     



    List by Yamini Ravichandran

    TAGC 2020

    Preprints recently presented at the virtual Allied Genetics Conference, April 22-26, 2020. #TAGC20

     



    List by Maiko Kitaoka, Madhuja Samaddar, Miguel V. Almeida, Sejal Davla, Jennifer Ann Black, Gautam Dey

    3D Gastruloids

    A curated list of preprints related to Gastruloids (in vitro models of early development obtained by 3D aggregation of embryonic cells)

     



    List by Paul Gerald L. Sanchez and Stefano Vianello

    ASCB EMBO Annual Meeting 2019

    A collection of preprints presented at the 2019 ASCB EMBO Meeting in Washington, DC (December 7-11)

     



    List by Madhuja Samaddar, Ramona Jühlen, Amanda Haage, Laura McCormick, Maiko Kitaoka

    EDBC Alicante 2019

    Preprints presented at the European Developmental Biology Congress (EDBC) in Alicante, October 23-26 2019.

     



    List by Sergio Menchero, Jesus Victorino, Teresa Rayon, Irepan Salvador-Martinez

    EMBL Seeing is Believing – Imaging the Molecular Processes of Life

    Preprints discussed at the 2019 edition of Seeing is Believing, at EMBL Heidelberg from the 9th-12th October 2019

     



    List by Gautam Dey

    SDB 78th Annual Meeting 2019

    A curation of the preprints presented at the SDB meeting in Boston, July 26-30 2019. The preList will be updated throughout the duration of the meeting.

     



    List by Alex Eve

    Lung Disease and Regeneration

    This preprint list compiles highlights from the field of lung biology.

     



    List by Rob Hynds

    Young Embryologist Network Conference 2019

    Preprints presented at the Young Embryologist Network 2019 conference, 13 May, The Francis Crick Institute, London

     



    List by Alex Eve

    Pattern formation during development

    The aim of this preList is to integrate results about the mechanisms that govern patterning during development, from genes implicated in the processes to theoritical models of pattern formation in nature.

     



    List by Alexa Sadier

    BSCB/BSDB Annual Meeting 2019

    Preprints presented at the BSCB/BSDB Annual Meeting 2019

     



    List by Gautam Dey

    Zebrafish immunology

    A compilation of cutting-edge research that uses the zebrafish as a model system to elucidate novel immunological mechanisms in health and disease.

     



    List by Shikha Nayar
    Close