Close

Cell Polarity

Recent research from the field of cell polarity is summarized in this list of preprints. It comprises of studies focusing on various forms of cell polarity ranging from epithelial polarity, planar cell polarity to front-to-rear polarity.

List by Yamini Ravichandran

Preprints:

Transcriptional control of apical protein clustering drives de novo cell polarity establishment in the early mouse embryo

Meng Zhu, Peizhe Wang, Charlotte E. Handford, Jie Na, Magdalena Zernicka-Goetz

http://biorxiv.org/content/early/2020/02/10/2020.02.10.942201.abstract

This early mammalian embryo study focuses on factors regulating the establishment of cell polarity in embryos which is required for the segregation of the inner cell mass and extra-embryonic trophectoderm. Their findings strongly propose that the transcription of Tfap2c, Tead and RhoA are key for the onset of de novo cell polarity establishment in embryos.

Distinct activities of Scrib module proteins organize epithelial polarity

Mark J. Khoury, David Bilder

https://www.biorxiv.org/content/10.1101/866863v1

This Drosophila follicular epithelium study identifies distinct functions of the three Scribble module proteins, separating their independent roles in a linear localization hierarchy from their synergistic roles in apical polarity antagonism. One key finding they demonstarte is that of the role of Dlg in stabilization of Scrib cortically. This is neither via Dlg’s GUK domain, nor via a possible regulation of Scrib palmitoylation by Dlg but via Dlg’s SH3 domain.

A fence function for adherens junctions in epithelial cell polarity

Mario Aguilar-Aragon, Alex Tournier, Barry J Thompson

https://www.biorxiv.org/content/10.1101/605808v1

This Drosophila study highlights that adherens junctions(AJs) are mainly required for controlling apico-basal domain sizes in epithelial cell polarity maintenance. Emphasizing that AJs are not necessarily required for the formation of the apical domain itself. A key finding they describe to support this is that AJs act as diffusion barriers to restrict the spreading of polarity components in epithelial cells.

Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity and functioning

Liu He, Robbelien Kooistra, Ravi Das, Ellen Oudejans, Eric V. van Leen, Johannes Ziegler, Sybren Portegies, Bart de Haan, Anna S. van Regteren Altena, Riccardo Stucchi, Maarten A. F. Altelaar, Stefan Wieser, Michael Krieg, Casper C. Hoogenraad, Martin Harterink

https://www.biorxiv.org/content/10.1101/783837v1

This C.elegans PVD neuron study identifies a complex responsible for the cortical tethering of microtubules. The complex comprises of UNC-119/Ankyrin/CRMP with CRMP being the micotubule associated protein. This sheds more light on the specific oragnization of the micotubule cytoskeleton which is one of the crucial factors required for establishing and maintaining neuronal polarity.

Apical restriction of the planar cell polarity component VANGL in pancreatic ducts is required to maintain epithelial integrity

Lydie Flasse, Siham Yennek, Cédric Cortijo, Irene Seijo Barandiaran, Marine R-C Kraus, Anne Grapin-Botton

https://www.biorxiv.org/content/10.1101/778332v1

A mammalian embryo study focusing on understanding the polarization of planar cell polarity components using a complex tubular epithelium namely the mammalian pancreas unlike previous studies which use flat epithelia. Their key finding being that VANGL is apically localized in ductal cells exhibiting PCP which is also essential for epithelial integrity.

Emergence of single cell mechanical behavior and polarity within epithelial monolayers drives collective cell migration

Shreyansh Jain, Victoire M.L. Cachoux, Gautham H.N.S. Narayana, Simon de Beco, Joseph D’Alessandro, Victor Cellerin, Tianchi Chen, Mélina L. Heuzé, Philippe Marcq, René-Marc Mège, Alexandre J. Kabla, Chwee Teck Lim, Benoit Ladoux

https://www.biorxiv.org/content/10.1101/2019.12.16.875567v1

An in-vitro study using MDCK cells seeded on ring micropatterns to address the onset of front-to-rear polarization. Confluent cells polarize and migrate in a rotational fashion within the rings.  Their key finding being that the maintenance of coordinated collective migration requires the establishment of a front-to-rear polarity axis within each cell but does not require the maintenance of cell-cell junctions.

Scribble and Discs-large direct adherens junction positioning and supermolecular assembly to establish apical-basal polarity

Teresa T. Bonello, Mark Peifer

http://biorxiv.org/lookup/doi/10.1101/654509

A Drosophila embryo study performed to address the role of Scrib/Dlg module in the initiation of apico-basal polarization via regulating players upstream of adherens junctions positioning. They identify multiple roles for Scrib/Dlg module in polarity initiation. One key role of the many highlighted in this study is that Scrib/Dlg module maybe regulating Par-1 to achieve onset of polarization.

Apical transport of Crumbs maintains epithelial cell polarity

M Aguilar-Aragon, G Fletcher, BJ Thompson

https://www.biorxiv.org/content/10.1101/592311v1

This Drosophila follicular epithelium study demonstrates that polarized trafficking of Crb containing Rab11-positive endosomes is driven by Dyenin along micotubules and via MyoV along actin filaments. In addition, they confirm the collective role of apical FERM domain containing proteins in promoting Crb polarization.

Categories: cell biology , developmental biology

 

Posted on: 1st May 2020

(No Ratings Yet)




  • Have your say

    Your email address will not be published. Required fields are marked *

    This site uses Akismet to reduce spam. Learn how your comment data is processed.

    Sign up to customise the site to your preferences and to receive alerts

    Register here

    Also in the cell biology category:

    BioMalPar XVI: Biology and Pathology of the Malaria Parasite

    [under construction] Preprints presented at the (fully virtual) EMBL BioMalPar XVI, 17-18 May 2020 #emblmalaria

     



    List by Gautam Dey, Samantha Seah

    1

    TAGC 2020

    Preprints recently presented at the virtual Allied Genetics Conference, April 22-26, 2020. #TAGC20

     



    List by Maiko Kitaoka, Madhuja Samaddar, Miguel V. Almeida, Sejal Davla, Jennifer Ann Black, Gautam Dey

    3D Gastruloids

    A curated list of preprints related to Gastruloids (in vitro models of early development obtained by 3D aggregation of embryonic cells)

     



    List by Paul Gerald L. Sanchez and Stefano Vianello

    ECFG15 – Fungal biology

    Preprints presented at 15th European Conference on Fungal Genetics 17-20 February 2020 Rome

     



    List by Hiral Shah

    ASCB EMBO Annual Meeting 2019

    A collection of preprints presented at the 2019 ASCB EMBO Meeting in Washington, DC (December 7-11)

     



    List by Madhuja Samaddar, Ramona Jühlen, Amanda Haage, Laura McCormick, Maiko Kitaoka

    EMBL Seeing is Believing – Imaging the Molecular Processes of Life

    Preprints discussed at the 2019 edition of Seeing is Believing, at EMBL Heidelberg from the 9th-12th October 2019

     



    List by Gautam Dey

    Autophagy

    Preprints on autophagy and lysosomal degradation and its role in neurodegeneration and disease. Includes molecular mechanisms, upstream signalling and regulation as well as studies on pharmaceutical interventions to upregulate the process.

     



    List by Sandra Malmgren Hill

    Lung Disease and Regeneration

    This preprint list compiles highlights from the field of lung biology.

     



    List by Rob Hynds

    Cellular metabolism

    A curated list of preprints related to cellular metabolism at Biorxiv by Pablo Ranea Robles from the Prelights community. Special interest on lipid metabolism, peroxisomes and mitochondria.

     



    List by Pablo Ranea Robles

    BSCB/BSDB Annual Meeting 2019

    Preprints presented at the BSCB/BSDB Annual Meeting 2019

     



    List by Gautam Dey

    MitoList

    This list of preprints is focused on work expanding our knowledge on mitochondria in any organism, tissue or cell type, from the normal biology to the pathology.

     



    List by Sandra Franco Iborra

    Biophysical Society Annual Meeting 2019

    Few of the preprints that were discussed in the recent BPS annual meeting at Baltimore, USA

     



    List by Joseph Jose Thottacherry

    ASCB/EMBO Annual Meeting 2018

    This list relates to preprints that were discussed at the recent ASCB conference.

     



    List by Gautam Dey, Amanda Haage

    Also in the developmental biology category:

    Cell Polarity

    Recent research from the field of cell polarity is summarized in this list of preprints. It comprises of studies focusing on various forms of cell polarity ranging from epithelial polarity, planar cell polarity to front-to-rear polarity.

     



    List by Yamini Ravichandran

    TAGC 2020

    Preprints recently presented at the virtual Allied Genetics Conference, April 22-26, 2020. #TAGC20

     



    List by Maiko Kitaoka, Madhuja Samaddar, Miguel V. Almeida, Sejal Davla, Jennifer Ann Black, Gautam Dey

    3D Gastruloids

    A curated list of preprints related to Gastruloids (in vitro models of early development obtained by 3D aggregation of embryonic cells)

     



    List by Paul Gerald L. Sanchez and Stefano Vianello

    ASCB EMBO Annual Meeting 2019

    A collection of preprints presented at the 2019 ASCB EMBO Meeting in Washington, DC (December 7-11)

     



    List by Madhuja Samaddar, Ramona Jühlen, Amanda Haage, Laura McCormick, Maiko Kitaoka

    EDBC Alicante 2019

    Preprints presented at the European Developmental Biology Congress (EDBC) in Alicante, October 23-26 2019.

     



    List by Sergio Menchero, Jesus Victorino, Teresa Rayon, Irepan Salvador-Martinez

    EMBL Seeing is Believing – Imaging the Molecular Processes of Life

    Preprints discussed at the 2019 edition of Seeing is Believing, at EMBL Heidelberg from the 9th-12th October 2019

     



    List by Gautam Dey

    SDB 78th Annual Meeting 2019

    A curation of the preprints presented at the SDB meeting in Boston, July 26-30 2019. The preList will be updated throughout the duration of the meeting.

     



    List by Alex Eve

    Lung Disease and Regeneration

    This preprint list compiles highlights from the field of lung biology.

     



    List by Rob Hynds

    Young Embryologist Network Conference 2019

    Preprints presented at the Young Embryologist Network 2019 conference, 13 May, The Francis Crick Institute, London

     



    List by Alex Eve

    Pattern formation during development

    The aim of this preList is to integrate results about the mechanisms that govern patterning during development, from genes implicated in the processes to theoritical models of pattern formation in nature.

     



    List by Alexa Sadier

    BSCB/BSDB Annual Meeting 2019

    Preprints presented at the BSCB/BSDB Annual Meeting 2019

     



    List by Gautam Dey

    Zebrafish immunology

    A compilation of cutting-edge research that uses the zebrafish as a model system to elucidate novel immunological mechanisms in health and disease.

     



    List by Shikha Nayar
    Close