Cellular metabolism

A curated list of preprints related to cellular metabolism at Biorxiv by Pablo Ranea Robles from the Prelights community. Special interest on lipid metabolism, peroxisomes and mitochondria.

List by Pablo Ranea Robles


Housing temperature influences exercise training adaptations in mice

Steffen H. Raun, Carlos H. Henriquez-Olguin, Iuliia Karavaeva, Mona Ali, Lisbeth L.V. Moller, Witold Kot, Josue L. Castro Mejia, Dennis Sandris Nielsen, Zach Gerhart-Hines, Erik A. Richter, Lykke Sylow

Another report on different physiological response of rodents under different housting temperatures.  Raun et al. show here that exercise-induced metabolic adaptations were blunted when mice were housed in thermoneutral conditions (30 °C).

Exercise does not induce browning of WAT at thermoneutrality and induces an oxidative, myogenic signature in BAT

Peter Aldiss, Jo E Lewis, Irene Lupini, David J Boocock, Amanda K Miles, Francis J P Ebling, Helen Budge, Michael E Symonds

Rodents are usually housed below their thermoneutral zone, but studies done at thermoneutrality show that their physiology is completely different, because brown adipose tissue (BAT) is hyperactive below thermoneutrality. Aldiss et al. show here that exercise does not induce browing of white adipose tissue (WAT) and a different response in BAT in rats housed at thermoneutrality (28 °C).

Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III

Chi-Lun Chang, Aubrey V. Weigel, Maria S. Ioannou, H. Amalia Pasolli, C. Shan Xu, David R. Peale, Gleb Shtengel, Melanie Freeman, Herald F. Hess, Craig Blackstone, Jennifer Lippincott-Schwartz

Peroxisomes interact with other organelles within the cell, but how they do it remain largely unknown. Here Chang et al. describe a tether between peroxisomes and lipid droplets that transfer fatty acids.

Presynaptic boutons that contain mitochondria are more stable

Robert M. Lees, James D. Johnson, Michael C. Ashby

Mitochondria are crucial for energy generation in the central nervous system and their dysfunction is related to multiple neurodegenerative diseases. Here, Lees et al. show that presynapses with more mitochondria are more stable, which open new avenues of research on the role of cellular metabolism and bioenergetics on synaptic structural plasticity.

Mitochondria form cholesterol tethered contact sites with the Nucleus to regulate retrograde response

Radha Desai, Daniel A East, Liana Hardy, James Crosby, Manuel Rigon, Danilo Faccenda, María Soledad Alvarez, Arti Singh, Marta Mainenti, Laura Kuhlman Hussey, Robert Bentham, Gyorgy Szabadkai, Valentina Zappulli, Gurtej Dhoot, Lisa E Romano, Xia Dong, Anne Hamechar-Brady, J Paul Chapple, Roland A. Fleck, Gema Vizcay-Barrena, Kenneth Smith, Michelangelo Campanella

Mitochondria and the nucleus communicate with each other but the molecular mechanisms and the players involved in this communication are not well known yet. Desai et al. report here for the first time Nucleus-Associated Mitochondria, which establish a new paradigm in organellar communication.

Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases

King Faisal Yambire, Lorena Fernandez-Mosquera, Robert Steinfeld, Christiane Muehle, Elina Ikonen, Ira Milosevic, Nuno Raimundo

Mitochondria and lysosomes are key organelles in lipid metabolism. Here, Faisal et al. show that mitochondrial biogenesis program is repressed in lysosomal storage disorders (LSDs), giving a plausible explanation of the mitochondrial defects usually found in patients with LSDs.

Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca2+

Jing Yong, Helmut Bischof, Marina Siirin, Anne Murphy, Roland Malli, Randal J. Kaufman

Proteins are folded and trafficked in the endoplasmic reticulum, but these processes require energyt in the form of ATP. Yong et al. describe a new intracellular communication between the ER and mitochondria, antagonized by Ca2+ signaling, that provides mitochondrial ATP to the ER.

Anabolic SIRT4 exerts retrograde control over TORC1 signalling by glutamine sparing in the mitochondria

Eisha Shaw, Manasi Talwadekar, Nitya Mohan, Aishwarya Acharya, Ullas Kolthur-Seetharam

Shaw et al. provide here a novel role of SIRT4 in the activation of mTORC1 in the fed state. Fine tuning of cellular metabolism is essential to maintain homeostasis in the transition between fed and fasted states. Here, they show that SIRT4 inhibits the conversion of glutamine to alpha-ketoglutarate in the mitochondria, which potentiates mTORC1 signaling, and regulates lipogenesis, autophagy and cell proliferation.

A comprehensive plasma metabolomics dataset for a cohort of mouse knockouts within the international mouse phenotyping consortium

Dinesh K Barupal, Ying Zhang, Tong Shen, Sili Fan, Bryan S Roberts, Patrick Fitzgerald, Benjamin Wancewicz, Luis Valdiviez, Gert Wohlgemuth, Gregory Byram, YingYng Choy, Bennett Haffner, Megan R. Showalter, Arpana Vaniya, Clayton S Bloszies, Jacob S Folz, Tobias Kind, Oliver Fiehn

Vast resource of untargeted and targeted metabolomics data from 30 knockout mice from the IMPC (International Mouse Phenotyping Consortium). Barupal et al. collected 220 plasma samples and detected 832 unique structurally identified metabolites from 124 chemical classes. All the raw data has been made available for further studies in this preprint.

Categories: biochemistry , cell biology , pathology , physiology


Posted on: 21st May 2019 , updated on: 29th May 2019

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