Preprint highlights, selected by the biological community

Autophagy

Preprints on autophagy and lysosomal degradation and its role in neurodegeneration and disease. Includes molecular mechanisms, upstream signalling and regulation as well as studies on pharmaceutical interventions to upregulate the process.

List by Sandra Malmgren Hill

Preprints:

The autophagic membrane tether ATG2A transfers lipids between membranes

Shintaro Maeda, Chinatsu Otomo, Takanori Otomo

https://www.biorxiv.org/content/10.1101/555441v1

This authors of this preprint uses clever in vitro experiment to show the lipid transferase activity of ATG2A, a function that could possibly be involved in expansion of the phagophore

Minimal Membrane Interactions Conferred by Rheb C-terminal Farnesylation are Essential for mTORC1 Activation

Brittany Angarola, Shawn M. Ferguson

https://www.biorxiv.org/content/10.1101/513473v2

Rheb farnesylation is required for its activation of mTOR, but does not require Rheb to be localized to the lysosome

A non-canonical arm of UPR^ER mediates longevity through ER remodeling and lipophagy

Joseph R. Daniele, Ryo Higuchi-Sanabria, Vidhya Ramachandran, Melissa Sanchez, Jenni Durieux, Sarah U. Tronnes, Joseph W. Paul, Daniel J. Esping, Samira Monshietehadi, Melissa G. Metcalf, Andrew Dillin

https://www.biorxiv.org/content/early/2018/11/15/471177

the authors of this preprint show that in C. elegans, the accumulation of misfolded proteins in the endoplasmic reticulum (ER) of neurons induces an unfolded protein response (UPR^ER) that is transmitted throughout the organism to yield a similar response in cells of the intestine. The group show that cells of the intestine responded by inducing the heatshock response, and that this cell non-autonomous signalling counteracted the age-related loss of protein quality control, and improved longevity.

Atlastins mediate selective autophagy of the endoplasmic reticulum

Jin Rui Liang, Emily Lingeman, Saba Ahmed, Jacob Corn

https://www.biorxiv.org/content/early/2018/03/01/274530

Atlastin family members are remodels the ER membrane, and are required for efficient ER-phagy.

Dynamin-2 facilitates Atg9 recycling from nascent autophagosomes

Alejandro Martorell Riera, Cinta Iriondo Martinez, Samuel Itskanov, Janos Steffen, Brett Roach, Carla M. Koehler, Alexander M. van der Bliek

https://www.biorxiv.org/content/early/2018/01/06/241901

Dynamin-2 facilitates the removal of Atg9 from the growing autophagosome membrane

Negative Regulation of Autophagy by UBA6-BIRC6–Mediated Ubiquitination of LC3

Rui Jia, Juan S. Bonifacino

https://www.biorxiv.org/content/10.1101/699124v1

This preprint shows that the E1 enzyme UBA6 and the E2/E3 ligase BIRCH6 selectively monoubiquitinates LC3-I, targeting it for proteasomal degradation and thereby functioning as a negative regulator of autophagy.

A conserved ATG2-GABARAP interaction is critical for phagophore closure

Mihaela Bozic, Luuk van den Bekerom, Beth A. Milne, Nicola Goodman, Lisa Roberston, Alan R. Prescott, Thomas J. Macartney, Nina Dawe, David G. McEwan

https://www.biorxiv.org/content/10.1101/624627v1

This preprint shows that ATG2A/B interacts with WIPI4 and LC3, and that only the LC3 interaction is necessary for its role in autophagy

Categories: cell biology , clinical trials , genetics , immunology , neuroscience , physiology

Posted on: 26th June 2019 , updated on: 18th July 2019

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