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Autophagy
Preprints on autophagy and lysosomal degradation and its role in neurodegeneration and disease. Includes molecular mechanisms, upstream signalling and regulation as well as studies on pharmaceutical interventions to upregulate the process.
List by Sandra Malmgren Hill
Preprints:
The autophagic membrane tether ATG2A transfers lipids between membranes
https://www.biorxiv.org/content/10.1101/555441v1
This authors of this preprint uses clever in vitro experiment to show the lipid transferase activity of ATG2A, a function that could possibly be involved in expansion of the phagophore
Minimal Membrane Interactions Conferred by Rheb C-terminal Farnesylation are Essential for mTORC1 Activation
https://www.biorxiv.org/content/10.1101/513473v2
Rheb farnesylation is required for its activation of mTOR, but does not require Rheb to be localized to the lysosome
A non-canonical arm of UPRER mediates longevity through ER remodeling and lipophagy
https://www.biorxiv.org/content/early/2018/11/15/471177
the authors of this preprint show that in C. elegans, the accumulation of misfolded proteins in the endoplasmic reticulum (ER) of neurons induces an unfolded protein response (UPRER) that is transmitted throughout the organism to yield a similar response in cells of the intestine. The group show that cells of the intestine responded by inducing the heatshock response, and that this cell non-autonomous signalling counteracted the age-related loss of protein quality control, and improved longevity.
Atlastins mediate selective autophagy of the endoplasmic reticulum
https://www.biorxiv.org/content/early/2018/03/01/274530
Atlastin family members are remodels the ER membrane, and are required for efficient ER-phagy.
Dynamin-2 facilitates Atg9 recycling from nascent autophagosomes
https://www.biorxiv.org/content/early/2018/01/06/241901
Dynamin-2 facilitates the removal of Atg9 from the growing autophagosome membrane
Negative Regulation of Autophagy by UBA6-BIRC6–Mediated Ubiquitination of LC3
https://www.biorxiv.org/content/10.1101/699124v1
This preprint shows that the E1 enzyme UBA6 and the E2/E3 ligase BIRCH6 selectively monoubiquitinates LC3-I, targeting it for proteasomal degradation and thereby functioning as a negative regulator of autophagy.
A conserved ATG2-GABARAP interaction is critical for phagophore closure
https://www.biorxiv.org/content/10.1101/624627v1
This preprint shows that ATG2A/B interacts with WIPI4 and LC3, and that only the LC3 interaction is necessary for its role in autophagy
Categories: cell biology , clinical trials , genetics , immunology , neuroscience , physiology
Posted on: 26th June 2019 , updated on: 18th July 2019
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Register hereAlso in the cell biology category:
Planar Cell Polarity – PCP
This preList contains preprints about the latest findings on Planar Cell Polarity (PCP) in various model organisms at the molecular, cellular and tissue levels.
| List by | Ana Dorrego-Rivas |
BioMalPar XVI: Biology and Pathology of the Malaria Parasite
[under construction] Preprints presented at the (fully virtual) EMBL BioMalPar XVI, 17-18 May 2020 #emblmalaria
| List by | Gautam Dey, Samantha Seah |
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Cell Polarity
Recent research from the field of cell polarity is summarized in this list of preprints. It comprises of studies focusing on various forms of cell polarity ranging from epithelial polarity, planar cell polarity to front-to-rear polarity.
| List by | Yamini Ravichandran |
TAGC 2020
Preprints recently presented at the virtual Allied Genetics Conference, April 22-26, 2020. #TAGC20
| List by | Maiko Kitaoka, Madhuja Samaddar, Miguel V. Almeida, Sejal Davla, Jennifer Ann Black, Gautam Dey |
3D Gastruloids
A curated list of preprints related to Gastruloids (in vitro models of early development obtained by 3D aggregation of embryonic cells)
| List by | Paul Gerald L. Sanchez and Stefano Vianello |
ECFG15 – Fungal biology
Preprints presented at 15th European Conference on Fungal Genetics 17-20 February 2020 Rome
| List by | Hiral Shah |
ASCB EMBO Annual Meeting 2019
A collection of preprints presented at the 2019 ASCB EMBO Meeting in Washington, DC (December 7-11)
| List by | Madhuja Samaddar, Ramona Jühlen, Amanda Haage, Laura McCormick, Maiko Kitaoka |
EMBL Seeing is Believing – Imaging the Molecular Processes of Life
Preprints discussed at the 2019 edition of Seeing is Believing, at EMBL Heidelberg from the 9th-12th October 2019
| List by | Gautam Dey |
Lung Disease and Regeneration
This preprint list compiles highlights from the field of lung biology.
| List by | Rob Hynds |
Cellular metabolism
A curated list of preprints related to cellular metabolism at Biorxiv by Pablo Ranea Robles from the Prelights community. Special interest on lipid metabolism, peroxisomes and mitochondria.
| List by | Pablo Ranea Robles |
BSCB/BSDB Annual Meeting 2019
Preprints presented at the BSCB/BSDB Annual Meeting 2019
| List by | Gautam Dey |
MitoList
This list of preprints is focused on work expanding our knowledge on mitochondria in any organism, tissue or cell type, from the normal biology to the pathology.
| List by | Sandra Franco Iborra |
Biophysical Society Annual Meeting 2019
Few of the preprints that were discussed in the recent BPS annual meeting at Baltimore, USA
| List by | Joseph Jose Thottacherry |
ASCB/EMBO Annual Meeting 2018
This list relates to preprints that were discussed at the recent ASCB conference.
| List by | Gautam Dey, Amanda Haage |
Also in the clinical trials category:
Autophagy
Preprints on autophagy and lysosomal degradation and its role in neurodegeneration and disease. Includes molecular mechanisms, upstream signalling and regulation as well as studies on pharmaceutical interventions to upregulate the process.
| List by | Sandra Malmgren Hill |
Antimicrobials: Discovery, clinical use, and development of resistance
Preprints that describe the discovery of new antimicrobials and any improvements made regarding their clinical use. Includes preprints that detail the factors affecting antimicrobial selection and the development of antimicrobial resistance.
| List by | Zhang-He Goh |
Also in the genetics category:
TAGC 2020
Preprints recently presented at the virtual Allied Genetics Conference, April 22-26, 2020. #TAGC20
| List by | Maiko Kitaoka, Madhuja Samaddar, Miguel V. Almeida, Sejal Davla, Jennifer Ann Black, Gautam Dey |
ECFG15 – Fungal biology
Preprints presented at 15th European Conference on Fungal Genetics 17-20 February 2020 Rome
| List by | Hiral Shah |
Autophagy
Preprints on autophagy and lysosomal degradation and its role in neurodegeneration and disease. Includes molecular mechanisms, upstream signalling and regulation as well as studies on pharmaceutical interventions to upregulate the process.
| List by | Sandra Malmgren Hill |
Zebrafish immunology
A compilation of cutting-edge research that uses the zebrafish as a model system to elucidate novel immunological mechanisms in health and disease.
| List by | Shikha Nayar |
Also in the immunology category:
Autophagy
Preprints on autophagy and lysosomal degradation and its role in neurodegeneration and disease. Includes molecular mechanisms, upstream signalling and regulation as well as studies on pharmaceutical interventions to upregulate the process.
| List by | Sandra Malmgren Hill |
Antimicrobials: Discovery, clinical use, and development of resistance
Preprints that describe the discovery of new antimicrobials and any improvements made regarding their clinical use. Includes preprints that detail the factors affecting antimicrobial selection and the development of antimicrobial resistance.
| List by | Zhang-He Goh |
Also in the neuroscience category:
ASCB EMBO Annual Meeting 2019
A collection of preprints presented at the 2019 ASCB EMBO Meeting in Washington, DC (December 7-11)
| List by | Madhuja Samaddar, Ramona Jühlen, Amanda Haage, Laura McCormick, Maiko Kitaoka |
SDB 78th Annual Meeting 2019
A curation of the preprints presented at the SDB meeting in Boston, July 26-30 2019. The preList will be updated throughout the duration of the meeting.
| List by | Alex Eve |
Autophagy
Preprints on autophagy and lysosomal degradation and its role in neurodegeneration and disease. Includes molecular mechanisms, upstream signalling and regulation as well as studies on pharmaceutical interventions to upregulate the process.
| List by | Sandra Malmgren Hill |
Young Embryologist Network Conference 2019
Preprints presented at the Young Embryologist Network 2019 conference, 13 May, The Francis Crick Institute, London
| List by | Alex Eve |
Also in the physiology category:
TAGC 2020
Preprints recently presented at the virtual Allied Genetics Conference, April 22-26, 2020. #TAGC20
| List by | Maiko Kitaoka, Madhuja Samaddar, Miguel V. Almeida, Sejal Davla, Jennifer Ann Black, Gautam Dey |
Autophagy
Preprints on autophagy and lysosomal degradation and its role in neurodegeneration and disease. Includes molecular mechanisms, upstream signalling and regulation as well as studies on pharmaceutical interventions to upregulate the process.
| List by | Sandra Malmgren Hill |
Cellular metabolism
A curated list of preprints related to cellular metabolism at Biorxiv by Pablo Ranea Robles from the Prelights community. Special interest on lipid metabolism, peroxisomes and mitochondria.
| List by | Pablo Ranea Robles |
Also in the cell biology category:
Shoot and root thermomorphogenesis are linked by a developmental trade-off
| Selected by | Alvaro Montiel-Jorda |
A Method to sort heterogenous cell populations based on migration in 2D and 3D environments
| Selected by | Mariana De Niz |
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Trackosome: a computational toolbox to study the spatiotemporal dynamics of centrosomes, nuclear envelope and cellular membrane
| Selected by | Mariana De Niz |
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Also in the clinical trials category:
Also in the genetics category:
Shoot and root thermomorphogenesis are linked by a developmental trade-off
| Selected by | Alvaro Montiel-Jorda |
Sexually Dimorphic DNA Damage Responses and Mutation Avoidance in the Mouse Germline
| Selected by | Jennifer Ann Black |
PINK1 and parkin shape the organism-wide distribution of a deleterious mitochondrial genome
| Selected by | Andrea Irazoki |
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Also in the immunology category:
Allergen-induced dendritic cell migration is controlled through Substance P release by sensory neurons
| Selected by | Pedro Papotto |
Antibody repertoire and gene expression dynamics of diverse human B cell states during affinity maturation
| Selected by | Connor Rosen |
Dectin-1 limits central nervous system autoimmunity through a non-canonical pathway
| Selected by | Pedro Papotto |
Also in the neuroscience category:
Persistence of quantal synaptic vesicle recycling following dynamin depletion
| Selected by | Julia Bleier |
An Atlas of Gene Regulatory Elements in Adult Mouse Cerebrum
| Selected by | Monica Tambalo |
Neural plate targeting by in utero nanoinjection (NEPTUNE) reveals a role for Sptbn2 in neurulation and abdominal wall closure
| Selected by | Martin Estermann |
Also in the physiology category:
Persistence of quantal synaptic vesicle recycling following dynamin depletion
| Selected by | Julia Bleier |
Metabolic scaling has diversified among species, despite an evolutionary constraint within species
| Selected by | Charlotte Nelson |
Female-specific upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity
| Selected by | Vaibhav Menon |