Sandra Malmgren Hill
I am a postdoc researcher with a background in molecular and cell biology. I have a broad interest in cell biology, and I am especially interested in protein quality control and its implications in aging and disease. I am also very passionate about topics related to the scientific work, such as gender equality in science, the movement for open access publishing, and science communication.
I finished my doctoral studies in the end of 2015, obtaining a PhD in biology at the Faculty of Science of University of Gothenburg, Sweden. I did my doctoral studies in the lab of Professor Thomas Nyström at the department of Chemistry and Molecular Biology, studying cellular aging and protein quality control in the unicellular yeast Saccharomyces cerevisiae.
In 2017 I started as a post-doc researcher in Professor David Rubinsztein’s lab at Cambridge University, funded by fellowships from EMBO and the Swedish Research council (VR). In my postdoctoral research project I am studying the regulation of autophagy, and the involvement of this process in neurodegeneration and cancer, working with mammalian cell culture and combining conventional techniques in biochemistry and cell biology with modern high-throughput methods of CRISPR/Cas9 screening and next-generation sequencing.
Quantitative analysis of the ubiquitin-proteasome system under proteolytic and folding stressors
ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer
Negative Regulation of Autophagy by UBA6-BIRC6–Mediated Ubiquitination of LC3
The autophagic membrane tether ATG2A transfers lipids between membranes
Minimal membrane interactions conferred by Rheb C-terminal farnesylation are essential for mTORC1 activation