Biophysical Society Meeting 2020
Phase Transition of RNA-protein Complexes into Ordered Hollow Condensates
Phase separation was a hot topic yet again at this year’s Biophysical Society Meeting. This preprint extends the landscape of liquid-liquid phase separation to some very interesting structures including hollow condensates.
Allosteric action of nucleotides on Hsp90 across several time- and length scales
Hsp90 is a dimeric molecular chaperone that is thought to aid protein folding by a series of conformational changes driven by ATP hydrolysis, although the precise mechanism is still unclear. Using single molecule fluorescence measurements and molecular dynamics simulations, this study demonstrates that nucleotide binding and hydrolysis affect the overall Hsp90 dimer by allosteric mechanisms.
Divergent ion selectivity and sensitivity to anti-hypertensive and non-steroidal anti-inflammatory drugs of DEG/ENaC/ASIC channels in C. elegans
The class of ion channels studied in this work are important drug targets for e.g. anti-inflammatory molecules. The authors here express five channels derived from C. elegans in Xenopus laevis oocytes to probe their properties in detail, leading to the surprising finding that they differ in their ion sensitivities and modulation by small molecules.
Kinetic fingerprint of antibody therapies predicts outcomes of Alzheimer clinical trials
Clinical trials for Alzheimer’s disease have been notoriously unsuccessful over the past years. This study uses elegant methods to demonstrate why one antibody that recently showed some effect in clinical trials acts on amyloid-beta aggregation via a unique mechanism.
A Tug of War Between Condensate Phases in a Minimal Macromolecular System
More phase separation: this study shows the interplay between four components in condensate formation, to better understand the behaviour of complex biomolecular mixtures such as membrane-less organelles.
Also in the biophysics category:
66th Biophysical Society Annual Meeting, 2022
Preprints presented at the 66th BPS Annual Meeting, Feb 19 - 23, 2022 (The below list is not exhaustive and the preprints are listed in no particular order.)
|List by||Soni Mohapatra|
EMBL Synthetic Morphogenesis: From Gene Circuits to Tissue Architecture (2021)
A list of preprints mentioned at the #EESmorphoG virtual meeting in 2021.
|List by||Alex Eve|
ASCB EMBO Annual Meeting 2019
A collection of preprints presented at the 2019 ASCB EMBO Meeting in Washington, DC (December 7-11)
|List by||Madhuja Samaddar et al.|
EMBL Seeing is Believing – Imaging the Molecular Processes of Life
Preprints discussed at the 2019 edition of Seeing is Believing, at EMBL Heidelberg from the 9th-12th October 2019
|List by||Dey Lab|
Preprints related to the application and development of biomolecular NMR spectroscopy
|List by||Reid Alderson|
Biophysical Society Annual Meeting 2019
Few of the preprints that were discussed in the recent BPS annual meeting at Baltimore, USA
|List by||Joseph Jose Thottacherry|
Also in the biophysics category:
Vesicles driven by dynein and kinesin exhibit directional reversals without external regulators
Genetically encoded multimeric tags for intracellular protein localisation in cryo-EM
Proteolysis-free cell migration through crowded environments via mechanical worrying