I am a PhD student co-supervised by Dr. Xi Huang and Dr. C.C. Hui at SickKids Research Institute in Toronto, Canada. My lab is interested in dissecting the roles of ion channels and tissue mechanics in the development of adult and pediatric brain tumours. Specifically, I am investigating the function of a potassium channel protein in medulloblastoma, one of the most common malignant brain cancers in children.
I am happy to share interesting and exciting new preprints on topics including but not limited to mechanosensation, cell migration, and cancer neuroscience!
Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2
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13 February 2024
Jade Chan
2D and 3D multiplexed subcellular profiling of nuclear instability in human cancer
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22 December 2023
Jade Chan
Small extracellular vesicles promote stiffness-mediated metastasis
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03 August 2023
Jade Chan, yohalie kalukula
Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness
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13 June 2023
Jade Chan
Functional synapses between small cell lung cancer and glutamatergic neurons
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13 February 2023
Jade Chan
Proteolysis-free cell migration through crowded environments via mechanical worrying
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05 December 2022
Jade Chan
An Arp2/3-cPLA2-NFκB axis acts as a Cell Shape Sensor to drive Homeostatic Migration of Dendritic Cells
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03 October 2022
Jade Chan
Mechanosensitive dynamics of lysosomes regulates the emergence of leader cells during collective cell migration
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12 September 2022
Jade Chan