I am a postdoctoral researcher at the Karolinska Institutet in Stockholm, Sweden. During my graduate studies at the University of Zurich, in Switzerland, I became interested in the cellular mechanisms ensuring the maintenance of genome stability. Generally, I am fascinated by the heterogenous nature of the most disparate biological processes and I enjoy using quantitative microscopy to investigate signaling events on a single cell level.
In my current project, I exploit amber suppression for tagging and studying the function of uncharacterized proteins generated by alternative mRNA translation. Amber suppression is a form of genetic code expansion that enables the targeted incorporation of non-canonical amino acids (ncAAs) into proteins of interest. Bioorthogonal chemical groups present on ncAAs enable a plethora of specific applications to probe, image and control protein functions.
An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput screens
Lorenzo Lafranchi
Akt/Foxo pathway activation switches apoptosis to senescence in short telomere zebrafish
Lorenzo Lafranchi
Developmental regulation of Canonical and small ORF translation from mRNA
Lorenzo Lafranchi
AGO1x prevents dsRNA-induced interferon signaling to promote breast cancer cell proliferation
Lorenzo Lafranchi
Synthetic pluripotent bacterial stem cells
Lorenzo Lafranchi
Multi-color single molecule imaging uncovers extensive heterogeneity in mRNA decoding
Lorenzo Lafranchi