Lorenzo Lafranchi

Karolinska Institutet

I am a postdoctoral researcher at the Karolinska Institutet in Stockholm, Sweden. During my graduate studies at the University of Zurich, in Switzerland, I became interested in the cellular mechanisms ensuring the maintenance of genome stability. Generally, I am fascinated by the heterogenous nature of the most disparate biological processes and I enjoy using quantitative microscopy to investigate signaling events on a single cell level.

In my current project, I exploit amber suppression for tagging and studying the function of uncharacterized proteins generated by alternative mRNA translation. Amber suppression is a form of genetic code expansion that enables the targeted incorporation of non-canonical amino acids (ncAAs) into proteins of interest. Bioorthogonal chemical groups present on ncAAs enable a plethora of specific applications to probe, image and control protein functions.

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