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Sergio Menchero

The Francis Crick Institute

I am a postdoctoral researcher in James Turner’ laboratory at the Francis Crick Institute (London, UK) supported by a HFSP-LT fellowship. My scientific interests include developmental biology and cell fate choices, specially from a transcriptional regulation perspective. I obtained my Degree in Biology from the Autonomous University of Madrid (Spain) in 2012. As an undergrad student I joined Miguel Manzanares’ laboratory at CNIC (Madrid, Spain) to study the regulation of the trophectoderm lineage in the mouse preimplantation embryo. I stayed in the same lab to perform a PhD thanks to a “FPI-Severo Ochoa” fellowship, and I focused on the transition of the totipotent embryo towards the activation of the first lineages. During my PhD, I had the opportunity to carry out a short stay in Kat Hadjantonakis’ lab at the Sloan Kettering Institute (New York, USA) learning live imaging. Currently, I am studying epigenetic mechanisms regulating X-chromosome inactivation during mammalian evolution.

Sergio Menchero has added 9 preLight posts

The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo

Giuliano Crispatzu, Rizwan Rehimi, Tomas Pachano, et al.



Selected by Sergio Menchero

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The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development

Trisha A. Macrae, Miguel Ramalho-Santos



Selected by Sergio Menchero

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LINE elements are a reservoir of regulatory potential in mammalian genomes

Maša Roller, Ericca Stamper, Diego Villar, et al.



Selected by Sergio Menchero

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Trophectoderm Potency is Retained Exclusively in Human Naïve Cells

Ge Guo, Giuliano Giuseppe Stirparo, Stanley Strawbridge, et al.



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The transcriptional legacy of developmental stochasticity

Sara Ballouz, Maria T. Pena, Frank M. Knight, et al.



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A single-cell transcriptomics CRISPR-activation screen identifies new epigenetic regulators of zygotic genome activation

Celia Alda-Catalinas, Danila Bredikhin, Irene Hernando-Herraez, et al.



Selected by Sergio Menchero

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Local rewiring of genome - nuclear lamina interactions by transcription

Laura Brueckner, Peiyao A Zhao, Tom van Schaik, et al.



Selected by Sergio Menchero

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Dynamics of Meiotic Sex Chromosome Inactivation and Pachytene Activation in Mice Spermatogenesis

Ábel Vértesy, Javier Frias-Aldeguer, Zeliha Sahin, et al.



Selected by Sergio Menchero

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Dynamic Erasure of Random X-Chromosome Inactivation during iPSC Reprogramming

Adrian Janiszewski, Irene Talon, Juan Song, et al.



Selected by Sergio Menchero

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