Ben Craske, Gaetan Dias Mirandela, Thibault Legal and Toni McHugh

Wellcome Centre for Cell Biology, University of Edinburgh

The Welburn lab

To maintain genomic integrity, eukaryotic cells must replicate their DNA faithfully and distribute it equally to daughter cells. Mitotic defects lead to aneuploidy and cancer. The accurate segregation of chromosomes is mediated by polarised and highly dynamic filaments, known as microtubules. Microtubules depend on motor proteins for their assembly into the mitotic spindle and for chromosome segregation. We aim to define how kinesin motors are modulated by their cargos to provide a specific output and how their coordinated activities are greater than the sum of their individual activities in vitro and in human cells. Our current goals are to define how (1) microtubule motors interact with the kinetochore and (2) the roles of mitotic motors in microtubule dynamics and spindle positioning.

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