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High-content Imaging-based Pooled CRISPR Screens in Mammalian Cells

Xiaowei Yan, Nico Stuurman, Susana A. Ribeiro, et al.

AND

Image-based pooled whole genome CRISPR screening for Parkin and TFEB subcellular localization

Gil Kanfer, Shireen A. Sarraf, Yaakov Maman, et al.

Frizzled-dependent Planar Cell Polarity without Wnt Ligands

Joyce J.S. Yu, Aude Maugarny-Calès, Stéphane Pelletier, et al.

AND

Wnt ligands are not required for planar cell polarity in the Drosophila wing or notum

Ben Ewen-Campen, Typhaine Comyn, Eric Vogt, et al.

Large-scale curvature sensing by epithelial monolayers depends on active cell mechanics and nuclear mechanoadaptation

Marine Luciano, Shi-Lei Xue, Winnok H. De Vos, et al.

The deubiquitinase Usp9x regulates PRC2-mediated chromatin reprogramming during mouse development

Trisha A. Macrae, Miguel Ramalho-Santos

Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity

Ghazal Babolmorad, Asna Latif, Niall M. Pollock, et al.

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Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity

Francisco Inesta-Vaquera, Panida Navasumrit, Colin J. Henderson, et al.

Discussion

Apico-basal cell compression regulates Lamin A/C levels in Epithelial tissues

K Venkatesan Iyer, Natalie A. Dye, Suzanne Eaton, et al.

Optoribogenetic control of regulatory RNA molecules

Sebastian Pilsl, Charles Morgan, Moujab Choukeife, et al.

FERONIA regulates FLS2 plasma membrane nanoscale dynamics to modulate plant immune signaling

Julien Gronnier, Christina M. Franck, Martin Stegmann, et al.

Discussion

Vinculin mediated axon growth requires interaction with actin but not talin

Pranay Mandal, Vivek Belapurkar, Deepak Nair, et al.

Cancer associated talin point mutations disorganise cell adhesion and migration

Latifeh Azizi, Alana R. Cowell, Vasyl V. Mykuliak, et al.

Amyotrophic lateral sclerosis associated mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex

MS Dyer, KE Lewis, AK Walker, et al.

A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic

Maria Alimova, Eriene-Heidi Sidhom, Abhigyan Satyam, et al.

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Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses

Willianne Hoepel, Hung-Jen Chen, Sona Allahverdiyeva, et al.

Discussion