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Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

Candice Gurbatri, Courtney Coker, Taylor E. Hinchliffe, et al.

AND

Programmable bacteria induce durable tumor regression and systemic antitumor immunity

Sreyan Chowdhury, Taylor E Hinchliffe, Samuel Castro, et al.

Discussion

Tousled-like kinase activity is required for transcriptional silencing and suppression of innate immune signaling

Sandra Segura-Bayona, Marina Villamor-Payà, Camille Stephan-Otto Attolini, et al.

Discussion

Snail induces epithelial cell extrusion through transcriptional control of RhoA contractile signaling and cell matrix adhesion

Kenneth Wee, Suroor Zadeh, Suzie Verma, et al.

Discussion

3D microenvironment stiffness regulates tumor spheroid growth and mechanics via p21 and ROCK

Anna V. Taubenberger, Salvatore Girardo, Nicole Träber, et al.

Discussion

A Bile Duct-on-a-Chip with Organ-Level Functions

Yu Du, Gauri Khandekar, Jessica Llewellyn, et al.

Oncogenic hijacking of a developmental transcription factor evokes therapeutic vulnerability for ROS-induction in Ewing sarcoma

Aruna Marchetto, Shunya Ohmura, Martin F. Orth, et al.

Discussion

A unicellular relative of animals generates an epithelium-like cell layer by actomyosin-dependent cellularization

Omaya Dudin, Andrej Ondracka, Xavier Grau-Bové, et al.

Mutations in the Insulator Protein Suppressor of Hairy Wing Induce Genome Instability

Shih-Jui Hsu, Emily C. Stow, James R. Simmons, et al.

Multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues

Adam K. Glaser, Nicholas P. Reder, Ye Chen, et al.

CXCR3-expressing metastasis-initiating cells induce and exploit a fibroblast niche in the lungs to fuel metastatic colonization

Maren Pein, Jacob Insua-Rodriguez, Jasmin Meier, et al.

SorCS1-mediated Sorting of Neurexin in Dendrites Maintains Presynaptic Function

Luis Filipe Ribeiro, Ben Verpoort, Julie Nys, et al.

Human Handedness: Genetics, Microtubules, Neuropsychiatric Diseases and Brain Language Areas

Akira Wiberg, Gwenaelle Douaud, Michael Ng, et al.

Discussion