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Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

Ruilin Tian, Anthony Abarientos, Jason Hong, et al.

Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity

Ghazal Babolmorad, Asna Latif, Niall M. Pollock, et al.

AND

Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity

Francisco Inesta-Vaquera, Panida Navasumrit, Colin J. Henderson, et al.

Discussion

Severe immunodeficiency in mice lacking DNA repair factors XLF and Mri

Sergio Castañeda-Zegarra, Qindong Zhang, Amin Alirezaylavasani, et al.

Discussion

Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival

Paolo Armando Gagliardi, Maciej Dobrzyński, Marc-Antoine Jacques, et al.

A hydraulic instability drives the cell death decision in the nematode germline

N. T. Chartier, A. Mukherjee, J. Pfanzelter, et al.

Discussion

PINK1 and parkin shape the organism-wide distribution of a deleterious mitochondrial genome

Arnaud Ahier, Nadia Cummins, Chuan-Yang Dai, et al.

Mitophagy protects beta cells from inflammatory damage in diabetes

Vaibhav Sidarala, Gemma L. Pearson, Vishal S. Parekh, et al.

EllipTrack: A Global-Local Cell-Tracking Pipeline for 2D Fluorescence Time-Lapse Microscopy

Chengzhe Tian, Chen Yang, Sabrina L. Spencer

Discussion

Transplantation of Muscle Stem Cell Mitochondria Rejuvenates the Bioenergetic Function of Dystrophic Muscle

Mahir Mohiuddin, Jeongmoon J. Choi, et al.

Discussion

Single-cell longitudinal analysis of SARS-CoV-2 infection in human bronchial epithelial cells

Neal G. Ravindra, Mia Madel Alfajaro, Victor Gasque, et al.

Discussion

Parallel CRISPR-Cas9 screens clarify impacts of p53 on screen performance

Anne Ramsay Bowden, David A. Morales Juarez, Matylda Sczaniecka-Clift, et al.

Robustness of epithelial sealing is an emerging property of local ERK feedbacks driven by cell elimination

Léo Valon, Florence Levillayer, Anđela Davidović, et al.